Composite medicine-containing and copper-containing IUD (Intrauterine Device) with cellular structure

A composite material, porous structure technology, applied in medical science, surgery, etc., can solve the problems of aggravating side effects such as IUD pain and bleeding, and achieve the effect of reducing side effects, pain and bleeding.

Active Publication Date: 2011-03-30
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, during the placement of the composite copper-containing IUD with a dense structure and the composite copper-containing IUD with a porous structure, it is inevit

Method used

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  • Composite medicine-containing and copper-containing IUD (Intrauterine Device) with cellular structure
  • Composite medicine-containing and copper-containing IUD (Intrauterine Device) with cellular structure
  • Composite medicine-containing and copper-containing IUD (Intrauterine Device) with cellular structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 25g of nano-copper particles, 70g of medical-grade low-density polyethylene (LDPE), and 5g of di-tert-butylhydroquinone (DTBHQ), and use methods such as premixing, blending, pressure injection or injection molding to prepare a dense Structured low-density polyethylene-based composite copper-containing IUD; then using ethyl acetate as the extraction solvent, the DTBHQ in the low-density polyethylene-based composite copper-containing IUD with a dense structure was removed in a Soxhlet extractor, Then vacuum-dry the composite IUD after extracting the porogen to remove the extraction solvent, and prepare a composite copper-containing IUD with a porous structure; then soak the composite copper-containing IUD with a porous structure in indole In the acetone solution of methacin, the indomethacin enters the pores with the solution, and then volatilizes to remove the acetone in the pores, so that a composite drug-containing copper-containing IUD with a porous structure is ...

Embodiment 2

[0031] Weigh 20g of micron copper particles, 65g of medical grade silicone rubber, 15g of tertiary butyl hydroquinone (TBHQ), add a small amount of vulcanizing agent, and use methods such as premixing, blending, pressure injection or injection molding to vulcanize, and first prepare The copper-containing IUD of the silicone rubber-based composite material with a dense structure is obtained; then, TBHQ in the copper-containing IUD of the silicone rubber-based composite material with a dense structure is removed by soaking for a long time with acetone as an extraction solvent, and then the porogen is extracted The final composite material IUD is vacuum-dried to remove the extraction solvent therein, and the composite material copper-containing IUD with a porous structure is prepared; then the composite material copper-containing IUD with a porous structure is soaked in ethanol containing indomethacin In the solution, the indomethacin enters the pores with the solution, and then v...

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PUM

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Abstract

The invention discloses a composite medicine-containing and copper-containing IUD (Intrauterine Device) with a cellular structure, comprising a polymer framework with the cellular structure, metal particles, antiphlogistic and hemostatic, wherein the metal particles, the antiphlogistic and the hemostatic are distributed in the polymer framework. The IUD is prepared by dipping a firstly prepared composite copper-containing IUD with the cellular structure into a solution of acetone or alcohol of indomethacin to make the indomethacin enter pores in the IUD along the solution, and then removing the acetone or alcohol in the pores in a volatizing manner. The composite medicine-containing and copper-containing IUD with the cellular structure can further release side-effects of pain and bleedingduring the initial implanting period of the composite copper-containing IUD with the cellular structure because of the loading of indomethacin medicine with antiphlogistic and hemostatic functions, besides completely succeeding the advantages of the composite copper-containing IUD with the cellular structure, namely greatly releasing the side-effects of bleeding, pain and the like caused by the traditional bare copper structure IUD.

Description

technical field [0001] The invention belongs to the field of composite materials and intrauterine devices, in particular to a composite drug-containing copper-containing intrauterine device with a porous structure. The intrauterine device includes a polymer skeleton with a porous structure and copper particles distributed therein With anti-inflammatory and hemostatic drugs, it is a new type of intrauterine device loaded with anti-inflammatory and hemostatic drugs in the composite copper-containing IUD with porous structure. technical background [0002] China is the most populous developing country in the world. At 02:00 on January 6, 2005, excluding Hong Kong, Macao Special Administrative Region and Taiwan Province, China's total population reached 1.3 billion, accounting for about 21% of the world's total population. %, equivalent to 1 / 3 of the total population of Asia, and 100 million more than the total population of all existing developed countries and regions in the wo...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/12A61L31/04
Inventor 夏先平谢长生朱长虹齐程蔡水洲
Owner HUAZHONG UNIV OF SCI & TECH
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