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Preparation method of traditional Chinese medicine aerosol for treating respiratory system diseases of birds

A respiratory disease and aerosol technology, which is applied in the field of veterinary drug preparation, can solve the problems of low blood flow at the airbag site, low drug bioavailability, large oral administration dose, etc., and achieves rapid absorption, strong practicability, The effect of fewer doses

Active Publication Date: 2012-02-22
南通市鑫海水产养殖专业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics are the first choice for the treatment of such respiratory diseases. However, due to the increasingly prominent problems of antibiotic resistance and drug residues, a series of Chinese herbal preparations have been developed in China in recent years, which have good curative effect on poultry respiratory diseases. The treatment of systemic diseases is now mostly administered by mixing feeding, oral administration, intramuscular injection, etc. The oral administration dose is large, and the drugs are easily destroyed in the gastrointestinal tract; "Barrier", which affects the efficacy of the medicine, and the blood flow in the poultry air sac is extremely small, so it is extremely difficult to take effect by oral administration or injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Add 250g of astragalus, 60g of schisandra, 100g of Magnolia officinalis and 200g of licorice into 8 times its mass of water, soak for 2 hours, extract under normal pressure reflux for 2 hours, and filter out the solution; add 5 times of its mass to the medicinal materials The water was refluxed at normal pressure for 2 hours, and the filtrate was filtered out; two times of filtrates were combined and concentrated, and the volume of the concentrated medicinal solution was 900ml, and the concentrated solution was placed in 80% (V / V) ethanol of 3 times the volume, and left to settle for 24 hours , filtered; the filtrate reclaims ethanol, concentrates the filtrate, and the volume of the concentrated medicinal solution is 730ml;

[0042] (2) After adding 80% (V / V) ethanol accounting for 8 times the mass of the above-mentioned medicinal material residue and mixing, leave it at room temperature for 24 hours, and filter; the filtrate reclaims ethanol, concentrates the filtra...

Embodiment 2

[0051] (1) Add 322g of astragalus, 33.4g of schisandra, 97g of Magnolia officinalis and 173g of licorice into 8 times its mass of water and soak for 2 hours, extract under normal pressure reflux for 2 hours, and filter out the solution; add 5 times its mass to the medicinal materials A certain amount of water was refluxed at normal pressure for 2 hours, and the filtrate was filtered out; two times of filtrates were combined and concentrated, and the volume of the concentrated medicinal solution was 660ml. Hour, filter; Filtrate reclaims ethanol, concentrates filtrate, and concentrated medicinal solution volume is 660ml;

[0052] (2) After adding 80% (V / V) ethanol accounting for 8 times of its mass to the residue of the above-mentioned medicinal materials and mixing, leave it at room temperature for 24 hours, and filter; the filtrate reclaims ethanol, concentrates the filtrate, and the volume of the concentrated medicinal solution is 650ml ;

[0053] (3) The concentrated solut...

Embodiment 3

[0061] (1) Add 222g of Astragalus membranaceus, 62g of Schisandra chinensis, 104g of Magnolia officinalis and 222g of licorice into water accounting for 8 times of its mass, soak for 2 hours, extract under normal pressure reflux for 2 hours, and filter out the solution; add 5 times of its mass to the medicinal materials The water was refluxed at normal pressure for 2 hours, and the filtrate was filtered out; two times of filtrates were combined and concentrated, and the volume of the concentrated medicinal solution was 1255ml, and the concentrated solution was placed in 80% (V / V) ethanol of 3 times the volume, and left to settle for 24 hours , filtered; the filtrate reclaims ethanol, concentrates the filtrate, and the volume of the concentrated medicinal solution is 630ml;

[0062] (2) After adding 80% (V / V) ethanol accounting for 8 times of its mass to the residue of the above-mentioned medicinal materials and mixing, leave it at room temperature for 24 hours, and filter; the ...

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Abstract

The invention provides a preparation method of traditional Chinese medicine aerosol for treating respiratory system diseases of birds, which comprises the specific steps of: 1, soaking astragalus root, the fruit of Chinese magnoliavine, officinal magnolia bark and liquorice root with water and then carrying out reflux extraction at normal pressure, filtering out a solution and condensing; 2, condensing residue of medicinal materials with 80 percent (V / V) alcohol; 3, mixing condensate, extracting and filtering, vacuum drying; 4, after crushing bee glue, extracting the crushed bee glue with absolute ethyl alcohol; 5, collecting bee glue extract, condensing recycled liquid, decompressing and drying; 6, adding traditional Chinese medicine powder prepared in the step 3 and the step 5 into deionized water or pure water to obtain a traditional Chinese medicine premixed solution; 7, under the condition of an anti-explosion environment, adding the absolute ethyl alcohol in a tank with a cover;8, continuously adding 99.6 percent glycerol; and 9, filtering with a filter, canning with a canning machine, and injecting a propellent after sterilizing and covering. The preparation method is simple, and is suitable for the requirement for the massive industrialized production.

Description

technical field [0001] The invention relates to a preparation method of veterinary medicine, in particular to a preparation method of traditional Chinese medicine aerosol used for treating poultry respiratory diseases. Background technique [0002] Respiratory diseases are concomitant infectious diseases caused by infectious factors, nutritional deficiencies, poor feed management and other factors that seriously affect the growth and production performance of poultry, resulting in low production performance of poultry and serious economic losses. Antibiotics are the first choice for the treatment of such respiratory diseases. However, due to the increasingly prominent problems of antibiotic resistance and drug residues, a series of Chinese herbal preparations have been developed in China in recent years, which have good curative effect on poultry respiratory diseases. The treatment of systemic diseases is now mostly administered by mixing feeding, oral administration, intram...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/575A61K9/12A61P11/00A61K35/64A61K35/644
Inventor 陈业金张树伟沈素芳马彦娜要瑞丽范惠章
Owner 南通市鑫海水产养殖专业合作社
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