Breviscapin-containing oral cavity spraying agent and preparation method thereof

Abstract

The invention discloses a breviscapin-containing oral cavity spraying agent, which is mainly prepared from the following components in percentage by mass: 5 to 10 percent of breviscapin, 3 to 6 percent of cosolvent, 0.1 to 1.5 percent of sorbefacient, 0.1 to 0.3 percent of preservative, 0.02 to 0.08 percent of flavoring agent and the balance of purified water. A preparation method of the oral cavity spraying agent comprises the following steps of: crushing the breviscapin, adding ethanol, heating for refluxing, and filtering and concentrating; after heating, regulating the pH value, standing, filtering, regulating the pH value of filter liquor, standing and performing suction filtration; precipitating with ethanol and washing with the water; adding methanol and active carbon, heating, filtering, concentrating the filter liquor, crystallizing, and washing and drying to obtain a coarse product; regulating the pH value of the coarse product, heating, centrifuging, allowing the filter liquor to pass through resin, eluting, concentrating the filter liquor under reduced pressure, performing suction filtration, regulating the pH value, standing and performing suction filtration to obtain precipitates, and washing and drying to obtain the breviscapin; and dissolving the breviscapin in the components, stirring uniformly, and filtering to obtain the spraying agent. The oral cavity spraying agent has quick response, high bioavailability and good effect of treating cardiovascular and cerebrovascular diseases, and is convenient to carry.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases such as coronary heart disease and angina pectoris and a preparation method thereof, in particular to a traditional Chinese medicine preparation containing scutellarin and a preparation method thereof. Background technique [0002] Coronary heart disease, angina pectoris and other cardiovascular and cerebrovascular diseases have become common and frequently-occurring diseases in emergency department, outpatient department and pre-hospital rescue. The rate is also increasing year by year, seriously threatening human health. Therefore, controlling the development of this disease, especially the acute onset of angina pectoris, is an urgent task in the medical field today. Therefore, new drugs and new dosage forms for treating these diseases have also become hot spots and difficulties in research and development at home and abroad. ...

AI Technical Summary

Problems solved by technology

At present, the preparations made from breviscapine include breviscapine injection, breviscapine for injection, breviscapine injection, breviscapine tablets, etc. However, the injections are inconvenient to use, not timely, and require professional medical personnel to carry out their preparations. Injection and other defects, tablets have low bioavailability, slow onset of action, and are difficult to be used to relieve the acute attack of angina pectoris and other deficiencies