Breviscapin-containing oral cavity spraying agent and preparation method thereof

A technology of oral spray and breviscapine, which is applied in the field of traditional Chinese medicine preparations containing breviscapine and its preparation, can solve the problems that it is difficult to relieve the acute attack of angina pectoris, the use of injections is inconvenient, and the bioavailability of tablets is low. Achieve the effects of easy industrial production, shortened absorption time, and rapid onset of effect

Inactive Publication Date: 2011-05-11
湖南恒生制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparations made from breviscapine include breviscapine injection, breviscapine for injection, breviscapine injection, breviscapine tablets, etc. However, the injections are inconvenient to use, not timely, and require profes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A breviscapine-containing oral spray of the present invention, the spray is mainly formulated from the following components in mass fraction:

[0024] Breviscapine 10%

[0025] L-Arginine 6%

[0026] Tween 80 1.0%

[0027] Chlorobutanol 0.15%

[0028] Sodium Saccharin 0.02%

[0029] Menthol 0.02% and

[0030] Purified water balance.

[0031] A preparation method of the oral spray containing breviscapine of the present embodiment, comprising the following steps:

[0032] (1) Preparation of crude scutellarin: Take scutellaria breviscapine (Scutellaria breviscapus) and grind it into a coarse powder, add 75% ethanol solution 4 times the mass of the coarse powder, then heat to 70°C to reflux and extract 3 times, each Control the time for each time within 3 hours, filter, combine the filtrates, and concentrate to an extract with a relative density of 1.2 (80°C); add an appropriate amount of water to the extract, stir well, heat to 80°C, and then use 5% hydrogen Adjust ...

Embodiment 2

[0037] A breviscapine-containing oral spray of the present invention, the spray is mainly formulated from the following components in mass fraction:

[0038] Breviscapine 10%

[0039] L-Arginine 5.5%

[0040] Sodium Lauryl Sulfate 1.5%

[0041] Paradigm Ethyl Ester 0.15%

[0042] Aspartame 0.02%

[0043] Menthol 0.03% and

[0044] Purified water balance.

[0045] A preparation method of the oral spray containing breviscapine of the present embodiment, comprising the following steps:

[0046](1) Preparation of crude scutellarin: Take scutellaria breviscapus (Scutellaria breviscapus) and grind it into a coarse powder, add 75% ethanol solution 4 times the mass of the coarse powder, then heat to 80°C to reflux and extract twice, each Control the time for each time within 3 hours, filter, combine the filtrates, and concentrate to an extract with a relative density of 1.2 (80°C); add an appropriate amount of water to the extract, stir well, heat to 80°C, and then use 5% hydrog...

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PUM

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Abstract

The invention discloses a breviscapin-containing oral cavity spraying agent, which is mainly prepared from the following components in percentage by mass: 5 to 10 percent of breviscapin, 3 to 6 percent of cosolvent, 0.1 to 1.5 percent of sorbefacient, 0.1 to 0.3 percent of preservative, 0.02 to 0.08 percent of flavoring agent and the balance of purified water. A preparation method of the oral cavity spraying agent comprises the following steps of: crushing the breviscapin, adding ethanol, heating for refluxing, and filtering and concentrating; after heating, regulating the pH value, standing, filtering, regulating the pH value of filter liquor, standing and performing suction filtration; precipitating with ethanol and washing with the water; adding methanol and active carbon, heating, filtering, concentrating the filter liquor, crystallizing, and washing and drying to obtain a coarse product; regulating the pH value of the coarse product, heating, centrifuging, allowing the filter liquor to pass through resin, eluting, concentrating the filter liquor under reduced pressure, performing suction filtration, regulating the pH value, standing and performing suction filtration to obtain precipitates, and washing and drying to obtain the breviscapin; and dissolving the breviscapin in the components, stirring uniformly, and filtering to obtain the spraying agent. The oral cavity spraying agent has quick response, high bioavailability and good effect of treating cardiovascular and cerebrovascular diseases, and is convenient to carry.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases such as coronary heart disease and angina pectoris and a preparation method thereof, in particular to a traditional Chinese medicine preparation containing scutellarin and a preparation method thereof. Background technique [0002] Coronary heart disease, angina pectoris and other cardiovascular and cerebrovascular diseases have become common and frequently-occurring diseases in emergency department, outpatient department and pre-hospital rescue. The rate is also increasing year by year, seriously threatening human health. Therefore, controlling the development of this disease, especially the acute onset of angina pectoris, is an urgent task in the medical field today. Therefore, new drugs and new dosage forms for treating these diseases have also become hot spots and difficulties in research and development at home and abroad. ...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/7048A61P9/10
Inventor 唐勇
Owner 湖南恒生制药股份有限公司
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