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Preparation method of enteric coated tablet with leech as raw material

An enteric-coated tablet and leech technology, which is applied in the direction of medical raw materials derived from leeches/helminths, medical preparations containing active ingredients, pharmaceutical formulations, etc. And other issues

Active Publication Date: 2011-05-11
CHONGQING DUOPUTAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese patent application No. 96102147.0 discloses that the whole medicine of leeches can be prepared into pharmaceutical preparations by methods such as freezing leeches, crushing, and low-temperature drying. Although this method can use the whole medicine of leeches as medicine, there is no research on pulverization, low-temperature drying and sterilization.
In the prior art, there is also a freeze-drying method to dry the leeches, but in this method, in the process of crushing the dry matter, a large amount of heat is generated during mechanical shearing, thereby reducing the overall activity of the leeches

Method used

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  • Preparation method of enteric coated tablet with leech as raw material
  • Preparation method of enteric coated tablet with leech as raw material
  • Preparation method of enteric coated tablet with leech as raw material

Examples

Experimental program
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Effect test

Embodiment 1

[0067] Get fresh and alive leeches, add water to wash, freeze, the freezing temperature is minus 5 ℃, and the number of days of freezing is 15 days. The frozen leeches are mashed with a tissue masher. Adding pharmaceutical excipients, the disintegrant is starch, hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, and the filler is starch, lactose, xylitol, mixed evenly, dried in vacuum at 30°C, pulverized, and used C O 60 Sterilized by radiation, granulated, adding lubricant micro-powder silica gel, compressed into tablets, coated with enteric coating, vested

Embodiment 2

[0069] Take fresh and live leeches, add water to wash them, and freeze them. The freezing temperature is minus 10°C, and the freezing period is 12 days. The frozen leeches are crushed with a tissue grinder at a speed of 5000 rpm, and the crushed materials are added for medicinal purposes. The excipient disintegrant is starch, cross-linked polyvinylpyrrolidone, the filler is lactose, pregelatinized starch, mannitol, sorbitol, and xylitol, mix well, dry in vacuum at 50°C, crush, and use C O 60 Sterilized by radiation, granulated, added with lubricant magnesium stearate, compressed into tablets, coated with enteric coating, vested

Embodiment 3

[0071] Get fresh and alive leeches, add water to wash, freeze, the freezing temperature is minus 5 ℃, and the number of days of freezing is 15 days. The frozen leeches are mashed with a tissue masher, and the masher speed is 3000 rpm. Adding pharmaceutical excipients, the disintegrating agent is starch; the filler is lactose and microcrystalline cellulose, mixed evenly, dried in vacuum at 50°C, pulverized, and used C O 60 Sterilized by radiation, granulated, added lubricant talcum powder, compressed into tablets, coated with enteric coating, vested

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Abstract

The invention discloses a preparation method of an enteric coated tablet with leech as a raw material, belonging to the technical field of traditional Chinese medicine. In the invention, research is carried out on the freezing temperature, the number of days of freezing, a mashing process, a low-temperature drying process and a sterilizing process, and the antithrombin activity is used an indicator to optimize a new process method. The process method is organic combination of different process parameters, i.e. the process method avoids high mechanical force and high temperature to achieve the effect of maintaining the activity of leech. By the process method provided by the invention, the enteric coated tablet prepared by using complete fresh live leech as medicine has higher antithrombin activity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of enteric-coated tablets with leeches as raw materials. Background technique [0002] Leeches, commonly known as leeches, grow and reproduce in inland freshwater waters. They are traditional special medicinal aquatic animals in my country. Modern pharmacological studies have shown that leeches have pharmacological effects such as: [0003] 1. The effect on blood. Hirudin can prevent the effect of thrombin on fibrin and hinder blood coagulation. Hirudin can still secrete a histamine-like substance, which can expand capillaries. Hirudin alcohol extract has a better effect on inhibiting blood coagulation. Peach kernel is the strongest, and the effect of hirudin preparation is stronger than that of water preparation. Hirudin 20mg can prevent the coagulation of 100g human blood. Leech water extract has obvious inhibitory effect o...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K9/28A61P7/02A61K38/58
CPCY02A50/30
Inventor 甘奇志曾新
Owner CHONGQING DUOPUTAI PHARMA
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