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Tool for accurate quantification in molecular mri

A susceptibility, minimization technique for measuring magnetic variables, adjusting magnetic variables, magnetic resonance measurements, etc., to solve problems such as insufficient quantification, inaccurate visualization of iron deposits, etc.

Active Publication Date: 2011-05-25
CORNELL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This low signal is related to the size and orientation of the voxel and may be disturbed by the absence of other signals, leading to imprecise visualization and insufficient quantification of iron deposits

Method used

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  • Tool for accurate quantification in molecular mri
  • Tool for accurate quantification in molecular mri
  • Tool for accurate quantification in molecular mri

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Experimental program
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Embodiment Construction

[0173] Content list

[0174] I. General description of the device, software and method.............................. ..............................35

[0175] II. Magnetosensitive imaging................................... ..........................................43

[0176] A. Mapping of arbitrary susceptibility distribution............................ ...................................43

[0177] B. Magnetic susceptibility imaging due to ill-posed inversion problems-forward problems from magnetization to MRI measurement field 43

[0178] C. Solve the problem of inversion from the magnetic field measured in MRI to the magnetization source............................... ..........45

[0179] 1. Magnetosensitive imaging using sparse regularization........................................ ....................45

[0180] (a) The realization of the solution for constrained minimization...................................... .................46

[0181] (b) Regularization parameters........

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Abstract

A method and an apparatus are provided for magnetic source magnetic resonance imaging. The method includes collecting energy signals from an object, providing additional information of characteristics of the object, and generating the image of the object from the energy signals and from the additional information such that the image includes a representation of a quantitative estimation of the characteristics. The additional information may comprise predetermined characteristics of the object, a magnitude image generated from the object, or magnetic signals collected from different relative orientations between the object and the imaging system. The image is generated by an inversion operation based on the collected signals and the additional information. The inversion operation minimizes a cost function obtained by combining the data extracted from the collected signals and the additional information of the object. Additionally, the image is used to detect a number of diagnostic features including microbleeds, contract agents and the like.

Description

[0001] Statement on Federally Funded Research and Development [0002] The present invention was completed with government support, and the authorization number issued by the National Institutes of Health is R01HL062994. The government has certain rights in this invention. Technical field [0003] The present invention generally relates to the analysis of image data, and more specifically, it relates to extracting from the image data the attributes of objects that are shown in the image data. [0004] Cross references to related applications [0005] This patent application requires US provisional patent application number 61 / 125752, US provisional patent application number 61 / 125709, US provisional patent application number 61 / 125710, US provisional patent application number 61 / 125713, US provisional patent application number 61 / 125727 and US The priority of provisional patent application No. 61 / 125704, these provisional patent applications were filed on April 28, 2008. Each of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/28G01R33/54G01R33/563
CPCG01R33/5601G01R33/5608G01R33/563G01R33/54
Inventor 王乙L·德·洛歇福尔B·克雷斯勒刘田P·史宾斯-梅勒
Owner CORNELL UNIVERSITY
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