Process and apparatus for coating a porous substrate with a coating liquid
A technology of substrates and components, applied in the direction of surface coating liquid devices, coatings, transportation and packaging, etc., can solve problems such as infeasibility and recovery rate problems
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example 1
[0103] It was desirable to determine whether a nonwoven substrate could be uniformly coated with the powder held in suspension when manually placed into the suspension.
[0104] A suspension was formed by mixing 1.7 g of the first biopowder and 0.3 g of the second biopowder at a solids-to-solvent ratio of 6% in 12 mL of dichloromethane and stirring the mixture. The first biological powder is obtained from plasma proteins by a cryopreservation process and comprises fibrinogen, albumin, immunoglobulins, fibronectin, von Willebrand factor (vWF), factor VIII, factor XIII and excipients. The approximate composition of the first biological powder, as a percentage of total solids, is as follows: 40% fibrinogen, 5% fibronectin, 13% albumin and immunoglobulin combined, approximately 1% factor VIII, XIII and vWF combined , and the rest are excipients. The second biological powder includes albumin, thrombin, calcium, stabilizers and excipients. The approximate composition of the second...
example 2
[0106] It was desired to determine the amount of powder retained in a non-woven substrate of biological powder held manually in a suspension of methyl perfluoropropyl ether solvent.
[0107] Suspensions containing biopowder compositions similar to those used in Example 1 were formed in stainless steel vessels with base dimensions of 2.25 inches by 2.25 inches. The first and second biological powder compositions were added to the stainless steel container in amounts of 0.4 g and 0.06 g, respectively. Methyl perfluoropropyl ether (HFE7000) was mixed with the biopowder composition in a stainless steel container to a powder relative amount of about 6% by weight. The stainless steel vessel was sonicated to generate a homogeneous dispersion of particles within the HFE7000. A pre-weighed 2 inch by 2 inch nonwoven substrate consisting of ORC-PG910 was manually placed into a stainless steel container such that four edges of the substrate contacted the suspension simultaneously. Coats...
example 3
[0109] It was desired to determine the effect of suspension density on the solids retention rate of nonwoven substrates manually placed into biopowder held in suspension in methyl perfluoropropyl ether solvent.
[0110] Suspensions of fibrinogen and thrombin powders in HFE7000 were prepared by stirring the mixed powders in test tubes containing solvent such that the solids to solvent ratios were 5.9 wt% (2 samples), 7.6 wt% and 15.0 wt%, respectively . A pre-weighed 4 inch by 4 inch ORC-vicryl nonwoven substrate sample was manually placed into a 4.25 inch by 4.25 inch tray containing the solids suspension. Care was taken to maintain the planarity of the substrate when placing it in the tray to ensure that all edges of the substrate were in contact with the liquid at the same time. The solvent was allowed to evaporate from the tray, and each coated sample was visually assessed for the degree of powder coverage (ie, uniformity) and weighed. Determine the amount of solids retai...
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