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Application of Tongxinluo in preparing medicament for treating pulmonary hypertension

A technology of pulmonary hypertension and Tongxinluo, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to improve reconstruction, treat pulmonary hypertension, and reduce pulmonary vascular resistance

Inactive Publication Date: 2011-07-06
荆志成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the therapeutic effect on pulmonary vascular disease and pulmonary hypertension has not been reported yet.

Method used

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  • Application of Tongxinluo in preparing medicament for treating pulmonary hypertension
  • Application of Tongxinluo in preparing medicament for treating pulmonary hypertension
  • Application of Tongxinluo in preparing medicament for treating pulmonary hypertension

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Experimental program
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Effect test

Embodiment 1

[0011] 1. Materials and methods

[0012] 1.1 Establishment of Rat Pulmonary Hypertension Model

[0013] Male SPF grade SD rats, weighing 200-220g. One-time subcutaneous injection of monocrotaline (Monocrotaline, MCT, 40mg / kg), 3 weeks later, right heart catheterization was used randomly to measure pulmonary artery pressure and hemodynamic parameters to identify whether the model was successfully established.

[0014] 1.2 Experimental grouping and drug intervention

[0015] (1) Model group (MCT group): 10 rats were given normal saline by intragastric administration after the pulmonary hypertension model was successfully established for 3 consecutive weeks.

[0016] (2) Tongxinluo low-dose group (Tongxinluo 0.2g·kg·d group): 10 rats were given Tongxinluo by intragastric administration after the pulmonary hypertension model was successfully established for 3 consecutive weeks.

[0017] (3) Tongxinluo medium-dose group (Tongxinluo 0.4g·kg·d group): 10 rats were given Tongxinluo...

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Abstract

The invention discloses application of Tongxinluo in preparing a medicament for treating pulmonary hypertension, relating to the field of pharmaceutical chemistry. Proven by experiments, the Tongxinluo can reduce the mean pulmonary artery pressure of a white rat with pulmonary hypertension, improve the cardiac output, reduce the pulmonary vascular resistance, and improve right ventricle remodeling and pulmonary vascular remodeling. Long-term usage of the Tongxinluo can effectively treat pulmonary hypertension and improve the right heart function.

Description

Technical field: [0001] The invention relates to the field of medicinal chemistry, in particular to the new application of Tongxinluo drug, especially the application of Tongxinluo in the preparation of drug for treating pulmonary hypertension. Background technique: [0002] Tongxinluo Capsule (Chinese Pharmacopoeia 2005 Edition Part One - Page 586) is a traditional Chinese medicine compound capsule developed by using the theory of collateral diseases in traditional Chinese medicine, under the guidance of the treatment methods of nourishing qi, promoting blood circulation and removing blood stasis, searching wind, relieving spasm and dredging collaterals. The main ingredients are leech, scorpion, centipede, cicada slough, and wood beetle, which are made of five kinds of insect medicines, together with ginseng, red peony root, borneol, sandalwood, balsamic incense, frankincense (made), jujube seed (stir-fried) and other medicines. It has the effects of nourishing qi and activ...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61P9/12A61K31/045A61K35/62A61K35/64A61K35/646A61K35/648
Inventor 荆志成张锐吴文汇刘岽蒋鑫袁平
Owner 荆志成
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