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Traditional Chinese medicine extract mixed preparation and application thereof

A technology of extract and Scutellaria baicalensis extract, which is applied in the field of mixed preparations of traditional Chinese medicine extracts, and can solve problems such as unreported

Inactive Publication Date: 2011-07-06
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the pharmacological properties of these three traditional Chinese medicines are clear, there are no reports in the prior art about the efficacy of the three combined use.

Method used

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  • Traditional Chinese medicine extract mixed preparation and application thereof
  • Traditional Chinese medicine extract mixed preparation and application thereof
  • Traditional Chinese medicine extract mixed preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 prepares Chinese medicine extract mixed preparation

[0018] The formula is: 100g of Scutellaria baicalensis extract, 100g of gardenia extract, 150g of Poria cocos extract, 100g of microcrystalline cellulose, 30g of crospovidone (PVPP), 7g of micropowdered silica gel, and 1g of magnesium stearate.

[0019] The preparation method is as follows:

[0020] (1) Scutellaria baicalensis extract, gardenia extract, Poria cocos extract and microcrystalline cellulose are thoroughly mixed, dried at 80°C for 2 hours, ground into fine powder, passed through a 100-mesh sieve, mixed, and set aside.

[0021] (2) Pass the crospovidone through a 100-mesh sieve, and set aside.

[0022] (3) Mix the mixture obtained in (1) with 1 / 3 of the PVPP prescription amount in equal increments, mix well, and pass through a 100-mesh sieve, 95% ethanol (volume fraction) soft material, pass through 24 mesh Sieve and granulate, and dry at 60°C for 30 minutes to obtain dry granules.

[0023]...

Embodiment 2

[0027] Embodiment 2 prepares the Chinese medicine extract mixed preparation

[0028] The formula is: 80g of Scutellaria baicalensis extract, 80g of gardenia extract, 100g of Poria cocos extract, 80g of microcrystalline cellulose, 30g of crospovidone (PVPP), 7g of micropowder silica gel, and 1g of magnesium stearate.

[0029] The preparation method is the same as in Example 1.

[0030] The Scutellaria baicalensis extract is obtained by the following preparation method: take 5000 g of Scutellaria baicalensis, add 12 times of 40% ethanol to reflux and extract twice, each time for 1.5 hours, recycle the ethanol, filter, combine the filtrate, concentrate the filtrate to 250ml, and adjust the pH with hydrochloric acid value to 1.5, keep warm at 60°C for 45 minutes, cool to room temperature, stand for 24 hours, filter, wash the residue with ethanol to pH 4.0, add 10 times of water and stir evenly, adjust the pH value to 7.0 with sodium hydroxide solution, dissolve Add an equal amoun...

Embodiment 3

[0033] The hepatoprotective and choleretic effect of the extract granule preparation (prepared in Example 1) of embodiment 3 on rats

[0034] 1. Effect on obstructive jaundice in rats caused by bile duct ligation:

[0035]Methods: 50 SD rats were randomly divided into normal control group, sham operation group, model control group, Usf capsule group, extract preparation dose group, extract preparation medium dose group, extract preparation high dose group, There were 5 groups, 10 rats in each group. Except for the normal control group, the rats in each group were separated from the common bile duct after laparotomy, and the upper and lower ends were ligated and cut off the common bile duct to form a model of obstructive jaundice. In the sham operation group, the common bile duct was separated after laparotomy but Not ligated, sutured. Each group of rats was intragastrically administered at 10ml / kg body weight 5 days after the operation, once a day, and the drug concentrations...

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Abstract

The invention discloses a traditional Chinese medicine extract mixed preparation which comprises a baical skullcap root extract, a cape jasmine fruit extract and an Indian buead extract, wherein the mixture ratio of the three is (80-100): (80-100): (100-150); and the content of scutelloside in the baical skullcap root extract is above 90%, the content of geniposide in the cape jasmine fruit extract is above 90%, and the content of polysaccharides in the Indian buead extract is above 50%. The traditional Chinese medicine extract mixed preparation has the effects of protecting liver and benefiting gallbladder, and can be used for preparing medicaments or health care products for protecting the liver and benefiting the gallbladder, or the medicaments for treating obstructive jaundice, or the medicament for treating cholestasis, or the medicaments for treating chronic alcoholic liver injury. The effects of the traditional Chinese medicine extract mixed preparation for and benefiting the gallbladder and protecting the cholestasis of rats caused by bile duct ligation and ANIT (alpha-naphthylisothiocyanate) and the alcoholic liver injury of the rats are obviously better than conventional control medicaments, and the liver injury degree and the icterus index can be significantly reduced.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract mixed preparation and application thereof. Background technique [0002] Scutellaria baicalensis, gardenia, and poria cocos are all common traditional Chinese medicines, and their pharmacological properties are as follows: [0003] Scutellaria baicalensis, the dried root of Scutellaria baicalensis Georgi, Labiatae, is cold in nature and bitter in taste, and returns to the lung, gallbladder, spleen, large intestine, and small intestine meridian. It is mainly produced in Hebei, Shanxi, Henan, Shaanxi, Inner Mongolia and Northeast China, and those produced in northern Hebei are the authentic medicinal materials. Clinical application: used for fever with dampness and temperature, chest tightness, thirsty and not wanting to drink, as well as damp-heat diarrhea, jaundice and other diseases. For damp-heat fever, it can be used in combination with talc, white cardoon kernel, and Poria cocos; for...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P1/16
Inventor 李贵海陆永辉孙付军孙力
Owner SHANDONG ACAD OF CHINESE MEDICINE
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