Organ mimic device with microchannels and methods of use and manufacturing thereof

A technology of organ imitation device and central microchannel, applied in chemical instruments and methods, methods of supporting/immobilizing microorganisms, methods of stress stimulating microbial growth, etc., can solve problems that have not been fully realized

Active Publication Date: 2011-07-13
CHILDRENS MEDICAL CENT CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Organ mimic device with microchannels and methods of use and manufacturing thereof
  • Organ mimic device with microchannels and methods of use and manufacturing thereof
  • Organ mimic device with microchannels and methods of use and manufacturing thereof

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Embodiment Construction

[0039] Exemplary embodiments described herein are organ mimicking devices and methods of use and manufacture thereof. Those skilled in the art will appreciate that the following description is illustrative only and is not intended to be limiting in any way. Other embodiments will be apparent to those skilled in the art. Reference is now made in detail to the implementation of the illustrative embodiments illustrated in the accompanying drawings. The same reference numerals are used in the drawings and the following description to refer to the same or similar items. It is to be understood that, for the sake of brevity, the phrase "an embodiment" includes more than one embodiment and, therefore, is not limited to only one embodiment.

[0040] According to this disclosure, the organ-mimicking device (also referred to as "the present device") is preferably used in an overall system incorporating sensors, computers, displays, and other computing devices utilizing software, data c...

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Abstract

The present invention discloses a system and a method including a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 61 / 081,080, filed July 16, 2008, which is hereby incorporated by reference in its entirety. [0003] governmental support [0004] This invention was made with Government support under Grant No. NIH R01 ES016665-01 A1, National Institutes of Health. The U.S. government has certain rights in it. technical field [0005] The present invention generally relates to an organ-mimicking device having microchannels and methods of use and manufacture thereof. Background technique [0006] Mechanical forces—push, pull, tension, pressure—are important regulators of cell development and behavior. The tensegrity provides the structure that determines how these physical forces are distributed within a cell or tissue and where and how they exert their respective effects. [0007] In the human body, most cells are constantly subjected to mechanical forces, such as ...

Claims

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Application Information

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IPC IPC(8): C12M3/06B01L3/00C12N5/07
CPCB01L2400/0472C12M25/02C12M23/16B01L3/5027B01L2400/0481B01L2300/0854B01L2200/0663B01L2300/163B01L2300/0887B01L2300/0877B01L3/50273B01L2400/0487C12M21/08C12M35/04G01N33/5088G01N33/5005G01N33/5091C12M23/58C12M29/10C12N5/0671C12N5/0688C12N5/0697C12N5/0606C12N5/061C12N5/0623C12N5/0647C12N5/0654C12N5/0662C12N5/0696
Inventor 唐纳德·E·英格贝尔胡东恩
Owner CHILDRENS MEDICAL CENT CORP
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