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Naproxen molecular imprinting hydrogel and preparation method thereof

A molecular imprinting, hydrogel technology, applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., to achieve the effect of simple preparation method and low production cost

Inactive Publication Date: 2012-11-21
TIANJIN JINLIN WATER TREATMENT SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the enantiomers of naproxen have the same molecular formula and similar basic physical and chemical properties, the resolution of chiral compounds is currently a technical problem to be solved urgently

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Synthesis of gel. Accurately weigh a certain amount of D-naproxen and place it in a beaker, add 50mL of absolute ethanol until it is completely dissolved, and make a solution with a concentration of 0.3mol / L, then add a certain amount of NIPAAm monomer to control the concentration of NIPAAm monomer at 2mol / L, magnetically stirred for 5 hours to fully dissolve and mix D-naproxen and NIPAAm. Add weighed MBAA as a cross-linking agent, control the concentration of the cross-linking agent to 0.15mol / L, and fill with nitrogen for about 20 minutes while stirring. Then add a certain amount of initiator AIBN, control the concentration at 0.03mol / L, continue to pass nitrogen for about 15 minutes, add a little accelerator TEMED, pour the solution into a self-made mold, and gel in a constant temperature water bath at 60°C for 16 hours. The prepared temperature-sensitive D-naproxen molecularly imprinted gel was soaked in distilled water for 4 days to remove unreacted monomers ...

Embodiment 2

[0029] (1) Synthesis of gel. Accurately weigh a certain amount of D-naproxen and place it in a beaker, add 50mL of absolute ethanol until it is completely dissolved, and make a solution with a concentration of 0.1mol / L, then add a certain amount of NIPAAm monomer to control the concentration of NIPAAm monomer at 1mol / L, magnetically stirred for 5 hours to fully dissolve and mix D-naproxen and NIPAAm. Add weighed MBAA as a cross-linking agent, control the concentration of the cross-linking agent to 0.20 mol / L, and fill with nitrogen for about 30 minutes while stirring. Then add a certain amount of initiator AIBN, control the concentration at 0.04mol / L, continue to pass nitrogen for about 20 minutes, add a little accelerator TEMED, pour the solution into a self-made mold, and gel in a constant temperature water bath at 70°C for 24 hours. The prepared temperature-sensitive D-naproxen molecularly imprinted gel was soaked in distilled water for 5 days to remove unreacted monomers...

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Abstract

The invention discloses naproxen molecular imprinting hydrogel and a preparation method thereof, relating to the field of intelligent high molecular material. The product adopts D-naproxen as template molecules, the D-naproxen is cross-linked and polymerized by initiation in an N-isopropyl acrylamide (NIPAAm) monomer solution, and then the template molecules in the polymer are removed by a physical means to obtain the molecular imprinting temperature-sensitive hydrogel with the space structure of the imprinted D-naproxen template molecules. The temperature-sensitive molecular imprinting hydrogel has an adsorptive action on the D-naproxen molecules, and can realize chiral separation of the D-naproxen and L-naproxen. The gel prepared in the invention adopts the routine temperature-sensitivehydrogel monomer raw material NIPAAm, and the preparation method is simple, dispenses with special equipment, has low production cost and is suitable for industrialized application.

Description

technical field [0001] The invention relates to the field of intelligent polymer materials, in particular to a hydrogel with good adsorption and separation functions for naproxen chiral drug molecules and a preparation method thereof. The hydrogel can be applied to the field of chiral drug separation of naproxen. Background technique [0002] Naproxen is a non-steroidal anti-inflammatory, antipyretic, and analgesic drug. There is a pair of optically active enantiomers. It is mainly used for the treatment of rheumatoid arthritis, rheumatic spondylitis, and postoperative pain relief. , is currently one of the largest sales of prescription drugs in the world. However, during the synthesis of naproxen, chiral molecules are often mixed together, and the D-naproxen configuration in the enantiomer has a therapeutic effect, while the L-naproxen configuration will bring great pain to the patient. . Therefore, it is of great practical significance to find a fast, simple and accurat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/54C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 赵义平陈莉张未来张青松李金苓王霞贺晓凌
Owner TIANJIN JINLIN WATER TREATMENT SCI & TECH CO LTD
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