Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ARA)

An antibody library and specific technology, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, chemical instruments and methods, anti-animal/human immunoglobulin, etc., can solve the problem of no such effect, etc. question

Inactive Publication Date: 2011-08-24
THERACLONE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Antibodies against this molecule have anti-cancer effects in the body, but some do not

Method used

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  • Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ARA)
  • Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ARA)
  • Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ARA)

Examples

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Embodiment Construction

[0065] Without further details, the invention will be fully developed by a person skilled in the art from the following description. The following descriptions are illustrative descriptions only, and are not intended to limit the rest of the disclosure of the present invention under any circumstances.

[0066] The efficacy and necessity of applying passive antibody therapy to the treatment of infectious diseases has been recognized by the public. (Keller and Stiehm. Clin. Microbiol. Rev. 13: 602-614 (2000); Oral HB. et al. MoI. Biotechnol. 21: 225-239 (2002); Casadevall et al. Nat. Rev. Microbiol. 2: 695 -703 (2004).) People who recover from viral infectious diseases and who receive therapeutic vaccines containing antibody populations can acquire lifelong immunity to viruses. These "natural antibodies" have pairs of heavy and light chains that are identical to those produced by the human immune system in action. Unlike human or humanized antibodies produced using recombinant...

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PUM

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Abstract

The invention provides antibody arrays specific for target antigens. Methods for discovery and compositions comprising native human antibodies, arrays comprising such antibodies, immortalized B cells expressing such antibodies and non-immortalized B cell libraries comprising B cells expressing such antibodies are provided. The invention provides a method for screening monoclonal antibodies for functional effects on cell surface molecules such as receptors using antibody repertoire arrays specific for target cell surface molecules. Functional antibodies directed to a target and therapeutics derived from such antibodies are also provided. High throughput and parallel screening for potentially therapeutic antibodies are provided. Antibodies directed to functional epitope clusters corresponding to a target and vaccines and therapeutics derived from such antibodies are also provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the priority of a provisional patent application, US Application Serial No. 61 / 083696, titled "Methods and Compounds for Discovering Specific Target Antibodies Using Antibody Repository Array (ARA)", filed on July 25, 2008. U.S. Serial No. 61 / 109418, entitled "Methods and Compositions for Discovering Specific Target Antibodies Using Antibody Repository Array (ARA)", filed on October 29, 2008. US Serial No. 61 / 159704, entitled "Functional Screening of Target-Specific Antibodies Using Antibody Repository Array (ARA)", filed on March 12, 2009. The entire contents thereof are hereby incorporated by reference into this application. technical field [0003] The invention generally relates to antibody sequences specific for a target antigen. Specifically, the present invention relates to methods of discovery involving natural human antibodies, antibody arrays containing the same, and human B cells expr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/00G01N33/50G01N33/543
CPCG01N33/6845C07K16/005C07K2317/21C07K16/00G01N33/6854C07K16/28A61P31/12
Inventor M·摩勒
Owner THERACLONE SCI
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