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Oil-in-water type notopterygium oil nano emulsion oral liquid and preparation method thereof

An emulsion oral liquid, oil-in-water type technology, applied in the field of medicine, can solve the problems of difficult processing into injections and tablets, unstable physical properties, low bioavailability, etc., and achieve improved sensory quality, clear and transparent appearance, The effect of simple preparation process

Inactive Publication Date: 2013-09-11
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Notopterygium oil is a fat-soluble drug, easily soluble in ethanol, methanol, ethyl acetate, etc., insoluble in water, unstable in physical properties, volatile, difficult to store, difficult to process into injections and tablets, and low in bioavailability
Therefore, its application is greatly limited

Method used

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  • Oil-in-water type notopterygium oil nano emulsion oral liquid and preparation method thereof
  • Oil-in-water type notopterygium oil nano emulsion oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation:

[0048] 1) Weigh 3.75g of RH-40, 0.75g of absolute ethanol, 0.02g of oil phase vitamin E oil, 0.02g of notopterygium oil, and 5.46g of distilled water for later use;

[0049] 2) Mix RH-40 and absolute ethanol and stir well;

[0050] 3) Add the oil phase vitamin E oil into the solution prepared in step 2) and stir well;

[0051] 4) Add notopterygium oil to the solution prepared in step 3), stir well, and slowly add distilled water dropwise at 20°C to 25°C and stir well until a clear, transparent, low-viscosity and fluid yellow or colorless transparent O / The W-type nanoemulsion is the oil-in-water type notopterygium oil nanoemulsion oral liquid of the present invention.

Embodiment 2

[0053] Tween-803g, glycerin 1.5g, 1,2-propanediol 0.5g, liquid paraffin 0.3g, notopterygium oil 0.1g, distilled water 4.6g.

Embodiment 3

[0055] Tween-803g, absolute ethanol 1.5g, 1,2-propanediol 0.5g, isopropyl myristate 0.15g, notopterygium oil 0.15g, distilled water 4.7g.

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Abstract

The invention discloses oil-in-water type notopterygium oil nano emulsion oral liquid and a preparation method thereof. The oral liquid is 10 to 100nm in grain size and consists of the following components in percentage by weight: 20 to 40 percent of surfactant, 4 to 20 percent of cosurfactant, 0.2 to 5 percent of oil phase, 0.2 to 8 percent of notopterygium oil and the balance of distilled water. The nano emulsion oral liquid has the advantages of improving the medical stability of the notopterygium oil during processing, improving the bioavailability of the notopterygium oil, prolonging the in vivo metabolism time of the notopterygium oil, lowering the consumption of auxiliary materials, lowering production cost and enjoying a wide market prospect in medical field.

Description

technical field [0001] The invention belongs to the field of medicine, relates to a new dosage form of notopterygium oil, in particular to a transparent and stable oil-in-water type notopterygium oil nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] The traditional Chinese medicine Notopterygium is the dried rhizome and root of Notopterygium incisum TingexH.T.Chang or No-topterygiumforbesiiBoiss., a perennial herb of Umbelliferae. Notopterygium is warm in nature and pungent in taste, and has the effects of dispelling exterior cold, expelling rheumatism, sharpening joints, and relieving pain. "Compendium of Materia Medica" said: "The function of notopterygium reaches the limbs, unblocks the blood vessels, eliminates evil spirits, and disperses wind-cold and rheumatism." Chinese Pharmacopoeia has been recorded. [0003] Notopterygium oil is one of the active ingredients of traditional Chinese medicine notopterygium, which has a wide rang...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/237A61P19/02A61P29/00A61P37/08
Inventor 欧阳五庆刘梅雪李雅
Owner NORTHWEST A & F UNIV
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