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Oil-in-water type dried orange peel oil nano-emulsion and preparation method thereof

A technology of nano-emulsion and tangerine peel, applied in the field of medicine, can solve problems such as difficulty in ensuring the stability of tangerine peel oil, affecting the curative effect of tangerine peel oil, and easy volatilization of tangerine peel oil, so as to achieve good solubilization, improve bioavailability, and improve sensory quality Effect

Inactive Publication Date: 2011-08-31
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional solid preparations have dosage forms such as tablets, granules, and capsules, but the tangerine peel oil is volatile, and the loss in the process is huge, and it is difficult to ensure the stability of the tangerine peel oil in the storage and application process; on the other hand, the tangerine peel oil It is a fat-soluble drug with poor water solubility and low bioavailability, which affects the curative effect of tangerine peel oil

Method used

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  • Oil-in-water type dried orange peel oil nano-emulsion and preparation method thereof
  • Oil-in-water type dried orange peel oil nano-emulsion and preparation method thereof
  • Oil-in-water type dried orange peel oil nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Mix 40.00g of Tween-80 with 8.00g of absolute ethanol, then add 3.00g of vitamin E, 3.00g of ethyl acetate and mix well, add 6.00g of tangerine peel oil and mix well, slowly add 40.00g of distilled water at room temperature, and add Stir with distilled water until a clear, transparent, colorless or yellow liquid with low viscosity and good fluidity is formed.

Embodiment 2

[0063] RH-40 50.00g, absolute ethanol 12.00g, ethyl acetate 15.00g, tangerine peel oil 0.01g, distilled water 22.99g.

Embodiment 3

[0065] Tween-80 45.00g, absolute ethanol 15.00g, ethyl acetate 3.00g, tangerine peel oil 12.00g, distilled water 25.00g.

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Abstract

The invention discloses an oil-in-water type dried orange peel oil nano-emulsion. The particle size of the nano-emulsion is 1-100nm. The nano-emulsion is prepared from the following raw materials in percentage by weight: 20.00-50.00% of surfactant, 4.00-24.00% of cosurfactant, 2.00-15.00% of oil phase, 0.01-12.00% of dried orange peel oil and the balance of distilled water, wherein the sum of the weight percents of the raw materials is 100%. The nano-emulsion disclosed by the invention is a yellow or colorless, clear and transparent liquid, has good stability, can improve the drug stability of the dried orange peel oil in the preparation process, improve the solubility and bioavailability of the dried orange peel oil and delay the drug metabolism time of the dried orange peel oil in bodies, and has wide market prospects in the medicine field.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new drug dosage form of tangerine peel oil, in particular to a clear and stable oil-in-water type tangerine peel oil nanoemulsion and a preparation method thereof. Background technique [0002] Tangerine peel is the dried and mature pericarp of Rutaceae plant orange and its cultivars. The pericarp is named after Chen Zheliang. Chenpi oil is the volatile oil extracted from tangerine peel, mostly composed of monoterpenes, sesquiterpenes and other terpenes, with D-limonene as the main component, and other γ-terpinene, β-monthly ene, α-pine oil Alcohol, α-pinene, β-pinene, α-terpinene, etc., have the functions of regulating qi and invigorating the spleen, drying dampness and resolving phlegm. Tangerine peel oil is more sensitive to the influence of air, sunlight and temperature, is easy to decompose and deteriorate, and is easy to volatilize at normal temperature. Traditional solid preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/107A61K47/34A61K47/44A61P1/14A61P11/10A61P11/14A61K47/14
Inventor 欧阳五庆尚朋朋李雅
Owner NORTHWEST A & F UNIV
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