Xanthine oxidase inhibitor for treating gout and preparation method thereof

A technology of xanthine oxidase and inhibitor, applied in the field of xanthine oxidase inhibitor and its preparation, can solve the problems of high toxicity and side effects, unsatisfactory treatment, etc., and achieve the effect of strongly inhibiting the activity of xanthine oxidase

Inactive Publication Date: 2011-10-05
WUHAN INSTITUTE OF TECHNOLOGY
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AI Technical Summary

Problems solved by technology

At present, Western medicine is not ideal for the treatment of this disease
Xanthine oxidase inhibitors with good clinical curative effect include allopurinol and febuxostat, but the side effects are relatively large

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1 Materials and methods

[0016] 1.1 Drugs and reagents

[0017] Hovenia dulcis, galangal, saffron, and licorice were purchased from Sanjiu Pharmacy on Xiongchu Street, Wuhan, and kudzu flower was purchased from Zhonglian Pharmacy. Xanthine oxidase (Beijing Century Shanshui Technology Company), xanthine (Sigma Company), quercetin (China Institute for the Control of Pharmaceutical and Biological Products), dimethyl sulfoxide (Amresco Company), and other reagents were of analytical grade.

[0018] 1. 2 Instruments

[0019] T6-New Century UV-Vis Spectrophotometer (Beijing General Instrument Co., Ltd.), AD204-N Electronic Analytical Balance (Mettler-Toledo Instrument Co., Ltd.), 600 type three water tank (Jintan Fuhua Instrument Co., Ltd. ), DZ-1BC vacuum drying oven (Tianjin Test Instrument Co., Ltd.), multi-functional pulverizer CDEB-30 (Shanghai Fine Machinery Factory).

[0020] 1.3 Preparation of compound ethanol extract

[0021] Weigh Hovenia dulcis, galangal, wate...

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PUM

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Abstract

The invention relates to a xanthine oxidase inhibitor for treating gout and a preparation method thereof. The preparation method for the xanthine oxidase inhibitor comprises the following steps of: 1) weighing 5.9 to 28.6 mass percent of hovenia dulcis thumb, 7.1 to 33.3 mass percent of lesser galangal root, 7.1 to 33.3 mass percent of fruit of princesplume ladysthumb, 7.1 to 33.3 mass percent ofliquoric root and 7.1 to 33.3 mass percent of pueraria flower; and 2) putting the medicinal materials weighed in the step 1) into a flask, adding 60 to 90 mass percent of ethanol in an amount which is 8 to 10 times the mass of the medicinal materials, refluxing and extracting for 30 to 50 minutes, filtering extracting solution for 3 times, mixing filtrate for 3 times, concentrating the filtrate and drying to form dry extract. The xanthine oxidase inhibitor has the advantages that: ethanol extract is an effective part of compound inhibitory xanthine oxidase, so a Chinese medicinal compound preparation prepared from the effective part has higher activity of the inhibitory xanthine oxidase, and is a competitive inhibitor.

Description

technical field [0001] The invention relates to a xanthine oxidase inhibitor for treating gout and a preparation method thereof. Background technique [0002] Gout has become a common disease that seriously threatens human health. It is listed by the United Nations as one of the twenty chronic diseases in the 21st century. The first major cause of it is the high level of uric acid in human blood. Xanthine oxidase inhibitors (Xanthine oxidase inhibitor, XOI) as urate-lowering drugs can inhibit the activity of xanthine oxidase (Xianthine Oxidase, XOD), reduce the synthesis of uric acid in the body, so as to achieve the purpose of treating gout. At present, Western medicine is not ideal for the treatment of this disease. Xanthine oxidase inhibitors with better clinical curative effect include allopurinol and febuxostat, but their side effects are relatively large. Traditional Chinese medicine has a wide range of sources, less toxic and side effects, and good curative effect. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P19/06
Inventor 黎莉邱敏芳戴立珍
Owner WUHAN INSTITUTE OF TECHNOLOGY
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