Xanthine oxidase inhibitor for treating gout and preparation method thereof

Abstract

The invention relates to a xanthine oxidase inhibitor for treating gout and a preparation method thereof. The preparation method for the xanthine oxidase inhibitor comprises the following steps of: 1) weighing 5.9 to 28.6 mass percent of hovenia dulcis thumb, 7.1 to 33.3 mass percent of lesser galangal root, 7.1 to 33.3 mass percent of fruit of princesplume ladysthumb, 7.1 to 33.3 mass percent ofliquoric root and 7.1 to 33.3 mass percent of pueraria flower; and 2) putting the medicinal materials weighed in the step 1) into a flask, adding 60 to 90 mass percent of ethanol in an amount which is 8 to 10 times the mass of the medicinal materials, refluxing and extracting for 30 to 50 minutes, filtering extracting solution for 3 times, mixing filtrate for 3 times, concentrating the filtrate and drying to form dry extract. The xanthine oxidase inhibitor has the advantages that: ethanol extract is an effective part of compound inhibitory xanthine oxidase, so a Chinese medicinal compound preparation prepared from the effective part has higher activity of the inhibitory xanthine oxidase, and is a competitive inhibitor.

Description

technical field [0001] The invention relates to a xanthine oxidase inhibitor for treating gout and a preparation method thereof. Background technique [0002] Gout has become a common disease that seriously threatens human health. It is listed by the United Nations as one of the twenty chronic diseases in the 21st century. The first major cause of it is the high level of uric acid in human blood. Xanthine oxidase inhibitors (Xanthine oxidase inhibitor, XOI) as urate-lowering drugs can inhibit the activity of xanthine oxidase (Xianthine Oxidase, XOD), reduce the synthesis of uric acid in the body, so as to achieve the purpose of treating gout. At present, Western medicine is not ideal for the treatment of this disease. Xanthine oxidase inhibitors with better clinical curative effect include allopurinol and febuxostat, but their side effects are relatively large. Traditional Chinese medicine has a wide range of sources, less toxic and side effects, and good curative effect. ...

AI Technical Summary

Problems solved by technology

At present, Western medicine is not ideal for the treatment of this disease

Xanthine oxidase inhibitors with good clinical curative effect include allopurinol and febuxostat, but the side effects are relatively large