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Application of hypericum japonicum thunb general flavone in preparing medicament for treating hepatic fibrosis

A technology for liver fibrosis and flavonoids, which is applied in drug combinations, medical preparations containing active ingredients, and digestive systems, etc., can solve the problems of small toxic and side effects, complex pathological mechanisms of liver fibrosis, and lack of curative effects. Anti-hepatic fibrosis, good mental and behavioral status, and high safety

Active Publication Date: 2011-10-12
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complexity of the pathological mechanism of liver fibrosis, there is still a lack of therapeutic drugs for liver fibrosis with significant curative effect and little side effects.
[0003] There are more than 200 million patients with various types of liver diseases in my country, including about 93 million hepatitis B virus carriers, about 30 million currently infected people, about 40 million hepatitis C virus carriers, and about 120 million fatty liver patients, with new cases every year More than 1 million people, the cost of treatment is more than 100 billion yuan, which has caused an extremely heavy economic burden to the society and brought great pain to countless patients and families

Method used

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  • Application of hypericum japonicum thunb general flavone in preparing medicament for treating hepatic fibrosis
  • Application of hypericum japonicum thunb general flavone in preparing medicament for treating hepatic fibrosis
  • Application of hypericum japonicum thunb general flavone in preparing medicament for treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Preparation of total flavonoids of Tianjihuang

[0022] Take an appropriate amount of Tianjihuang medicinal material, cut into sections, decoct three times with 12 times, 10 times, and 8 times the amount of water, each time for 1 hour, filter, combine the filtrates, and concentrate under reduced pressure to contain Tianjihuang medicinal material 0.5g / ml Add it to the pre-prepared polyamide column, first elute with distilled water until the color of the eluent is light, then add 60% ethanol for elution until the hydrochloric acid-magnesium powder reaction is negative, collect the alcohol lotion, concentrate to a relatively The concentrated solution with a density of 1.08-1.10 (60°C) is spray-dried under the conditions of an inlet air temperature of 100-200°C and an outlet air temperature of 50-150°C to obtain the total flavonoids of Tianjihuang. According to the above method, five batches of Tianjihuang medicinal materials were selected for extraction, and ...

Embodiment 2

[0027] Example 2: The effect of total flavonoids of Tianjihuang on liver fibrosis in rats caused by common bile duct ligation

[0028] 1. Experimental animals:

[0029] SD rats, SPF grade, half male and half male, provided by Guangdong Medical Experimental Animal Center, animal qualification certificate number: SCXK (Guangdong) 2008-0002.

[0030] Drug grouping and handling:

[0031] Normal control group: distilled water.

[0032] Model control group: the rat liver fibrosis model was induced by common bile duct ligation, and an equal volume of distilled water was given.

[0033] Low-dose group of total flavonoids of Tianjihuang: before the experiment, take total flavonoids of Tianjihuang (total flavonoid content is 63.5%), add distilled water to prepare a suspension with a concentration of 0.9 mg / ml.

[0034] Medium-dose group of total flavonoids of Tianjihuang: before the experiment, take total flavonoids of Tianjihuang (total flavonoids content is 63.5%), add distilled wa...

Embodiment 3

[0063] Example 3: The effect of total flavonoids of Tianjihuang on immune liver fibrosis in rats induced by pig serum

[0064] 1. Experimental animals:

[0065] SD rats, SPF grade, half male and half male, provided by Guangdong Medical Experimental Animal Center, animal qualification certificate number: SCXK (Guangdong) 2008-0002.

[0066] , Drug grouping and processing:

[0067] Normal control group: distilled water.

[0068] Model control group: the rat immune liver fibrosis model induced by pig serum was used, and an equal volume of distilled water was given.

[0069] Low-dose group of total flavonoids of Tianjihuang: before the experiment, take total flavonoids of Tianjihuang (total flavonoid content is 63.5%), add distilled water to prepare a suspension with a concentration of 0.9 mg / ml.

[0070] Medium-dose group of total flavonoids of Tianjihuang: before the experiment, take total flavonoids of Tianjihuang (total flavonoids content is 63.5%), add distilled water to p...

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Abstract

The invention relates to application of hypericum japonicum thunb general flavone in preparing medicament for treating hepatic fibrosis. The hypericum japonicum thunb general flavone is an effective component extracted from Hypericum japonicum Thunb. The invention further provides a medicinal composition for treating hepatic fibrosis, which comprises the hypericum japonicum thunb general flavone which has effective treatment dosage and serves as an active component, and pharmaceutically acceptable vectors. Animal experiments prove that: the hypericum japonicum thunb has good hepatic fibrosis resistance, has no toxic or side effect, and can be used for preparing the medicament for treating the hepatic fibrosis and for treating clinical hepatic fibrosis.

Description

technical field [0001] The invention relates to a new application of the total flavonoids of Tianjihuang, in particular to a new application of the total flavonoids of Tianjihuang for preparing a medicine for treating liver fibrosis. Background technique [0002] Liver fibrosis is the necessary link for most liver diseases including hepatitis, fatty liver, alcoholic liver, etc. to develop into cirrhosis and liver cancer. Studies have shown that 20% to 40% of patients with liver fibrosis eventually develop liver cirrhosis or even liver cancer. Professor Hans Popper, an international academic authority on liver diseases, proposed that "whoever can prevent liver fibrosis can cure most liver diseases", so effectively blocking the occurrence and development of liver fibrosis is of great significance to the prevention and treatment of liver cirrhosis and liver cancer. However, due to the complexity of the pathological mechanism of liver fibrosis, there is still a lack of therapeu...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16
CPCA61K31/7048A61K36/38A61P1/16
Inventor 苏薇薇李沛波王永刚彭维杨翠平吴忠
Owner SUN YAT SEN UNIV
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