Composition containing niclosamide and metaldehyde and compound suspension thereof

A technology of metaldehyde and spirulina, applied in biocides, biocides, molluscicides, etc., can solve the problems of difficulty in effectively controlling the prevalence of schistosomiasis, low efficacy of wettable powders, and easy pollution of the environment , achieve the effect of overcoming the problem of drug resistance, good molluscicide effect, and safe storage and transportation

Active Publication Date: 2013-08-28
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, both of them have the problems of drug difficulty and drug resistance, and it is difficult to effectively control the prevalence of schistosomiasis.
Moreover, both of them are insoluble in water, and the wettable powder has low drug efficacy, large dosage, easy drift of dust, easy to pollute the environment, and is inconvenient to use.

Method used

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  • Composition containing niclosamide and metaldehyde and compound suspension thereof
  • Composition containing niclosamide and metaldehyde and compound suspension thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: 15% spirulina + 1% metaldehyde suspending agent

[0019] In terms of mass percentage, spiroxamine 15%, metaldehyde 1%, fatty acid polyoxyethylene ether 2%, methylene bis-naphthalene sulfonate sodium salt 5%, calcium lignosulfonate 5%, ethylene glycol 5% %, 0.3% benzoic acid, 0.5% organic silicone defoamer, 0.2% Cathone, 0.3% xanthan gum, deionized water to make up to 100%. The components are uniformly mixed with a high-shear emulsifying disperser in this ratio, and ground to 2-3um by a multi-stage sand mill to obtain 15% spiroxamate + 1% metaldehyde SC.

Embodiment 2

[0020] Embodiment 2: 25% spirulina+1% metaldehyde suspending agent

[0021] In terms of mass percentage, 25% spiroxamine, 1% metaldehyde, 2% sodium lauryl sulfate, 5% sodium methylene bis-naphthalene sulfonate, 5% calcium lignosulfonate, ethylene glycol 5%, 0.3% benzoic acid, 0.5% organic silicone defoamer, 0.2% Cathone, 0.3% xanthan gum, deionized water to make up to 100%. The components are uniformly mixed with a high-shear emulsifying disperser in this ratio, and ground to 2-3um by a multi-stage sand mill to obtain 25% spiroxamate + 1% metaldehyde SC.

Embodiment 3

[0022] Embodiment 3: 30% spirulina + 1% metaldehyde suspending agent

[0023] In terms of mass percentage, spiroxamine 30%, metaldehyde 1%, alkylphenol polyoxyethylene ether 2%, polycarboxylate sodium salt 2%, methylene bis-naphthalene sulfonic acid sodium salt 3%, ethylene glycol 5% alcohol, 1% benzoic acid, 0.5% organosilicone defoamer, 0.2% Cathone, 0.2% xanthan gum, and grind to 2-3um by multi-stage sand mill to prepare 30% spiroxamate+1 % Metaldehyde SC.

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Abstract

The invention discloses a composition containing niclosamide and metaldehyde and a compound suspension thereof. The niclosamide and the metaldehyde are used as active ingredients of the composition, and the mass ratio of the niclosamide to the metaldehyde is (1-50):(1-10). The composition can be applied to preparation of medicaments for preventing and treating trematodiasis. The aqueous suspension containing the niclosamide and the metaldehyde comprises 1-50 percent of niclosamide, 1-10 percent of metaldehyde, 1-5 percent of wetting agent, 1-20 percent of dispersant, 1-10 percent of anti-freezing agent, 0.1-1 percent of preservative, 0.1-1 percent of pH regulator, 0.1-1 percent of defoaming agent, 0.1-2 percent of thickening agent and the balance of deionized water which complements the volume to 100 percent. The aqueous suspension has the advantages of large prevention and treatment spectrum, good oncomelania killing effect, nonuse of an organic solvent, low volatility, low toxicity,safety to people, animals and environments, low granularity, high suspension rate, convenience in use and obvious comprehensive and economic benefits.

Description

technical field [0001] The invention belongs to the field of prevention and treatment of schistosomiasis, in particular to a composition containing spiroxamine and metaldehyde and its water suspension. Background technique [0002] Spirocidal and metaldehyde are mainly used to kill molluscs to prevent and control the prevalence of schistosomiasis. At low concentrations, snailicide stimulates the aerobic metabolism of snails, and promotes the escape and climbing of snails. At high concentrations, it affects the tricarboxylic acid cycle and causes the death of snails; metaldehyde is also a widely used molluscicide. The outstanding advantage is that it can inhibit the climbing of snails and has low toxicity to aquatic organisms. [0003] However, both of them have the problems of drug difficulty and drug resistance, and it is difficult to effectively control the prevalence of schistosomiasis. And both are insoluble medicines in water, and its wettable powder drug effect is no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/24A01N37/40A01N25/04A01P9/00
Inventor 朱光飞梁晓天张申伟
Owner JIANGSU ESSENCE AGROCHEM
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