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Application of ginkgo extractive in preparing external preparation capable of treating skin disease

A technology of ginkgo extract and external preparation, which is applied in the fields of biomedicine and therapeutic cosmetics, can solve the problems of ginkgo extract, skin lesion deterioration, and side effects that have not yet been seen, and achieve the effect of wide range of functions, no side effects, and excellent curative effect

Inactive Publication Date: 2011-11-23
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antibacterial drugs, antiviral drugs or antifungal drugs are mostly used to treat infectious skin diseases, and corticosteroids are mostly used to treat inflammatory and allergic skin diseases. Although these drugs have temporary effects, rashes often appear after stopping the drugs. deterioration; and long-term application will cause many side effects
There is no report on the use of ginkgo extract in the preparation of external preparations for the treatment of inflammatory and allergic skin diseases

Method used

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  • Application of ginkgo extractive in preparing external preparation capable of treating skin disease
  • Application of ginkgo extractive in preparing external preparation capable of treating skin disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The ginkgo fruit outer testa is peeled off, dried in the sun, and crushed with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time . After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain Ginkgo biloba extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water.

[0019] Preparation of the gel: Sprinkle 10 g of Carbopol on the surface of 500 ml of distilled water, and swell overnight. Weigh 60 g of glycerin and 120 ml of propylene glycol, respectively add them to the swollen Carbopol, and grind them evenly to obtain a transparent g...

Embodiment 2

[0021] The ginkgo fruit outer testa is peeled off, dried in the sun, and crushed with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add distilled water with a solid-liquid ratio of 1:6 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours. After the leaching is finished, filter with a suction filter to collect the filtrate. The filtrate was concentrated. Vacuum-dried at 60°C to obtain Ginkgo biloba extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water.

[0022] Preparation of ointment: Take 5 g of the above-mentioned ginkgo extract extract, dissolve it in 100 ml of 95% ethanol solution, add 50 ml of triethanolamine therein, and heat to 70° C. 300g of paraffin, 300g of stearic acid, and 100ml of propylene glycol were respectively added and stirred to melt, supplemented with distilled water to a sufficient amount of 1000g, and stirred evenly to a pa...

Embodiment 3

[0024] The ginkgo fruit outer testa is peeled off, dried in the sun, and crushed with a pulverizer. Accurately take a certain amount of pulverized Ginkgo testa, add 80% petroleum ether with a material-to-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60 ° C, each extraction time is 4 Hour. After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum drying at 60°C to obtain Ginkgo biloba extract; properties: light brown extract, slightly smelly, soluble in alcohol, insoluble in water.

[0025] The preparation of tincture: get above-mentioned ginkgo extract extract 100g, dissolve in 600ml 95% ethanol solution, then add triethanolamine 50ml, propylene glycol 200ml stirring therein respectively, make up 95% ethanol solution to sufficient amount 1000ml...

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Abstract

The invention relates to an application of ginkgo extractive in preparing external preparation capable of treating skin diseases. The ginkgo extractive can be obtained from extractives of ginkgo leaves, fruits, testa, roots, stems and other positions with a chemical separation method. Extraction solvents can be organic solvents, such as ethanol, water, aether, sherwood oil and the like. The skin disease is infectious, inflammatory, allergic reaction or allergic dermatitis. The drug, cosmetics or disinfector external preparations containing ginkgo extractives contains 0.001-80wt% of ginkgo extractive, pharmaceutically commonly-used external preparation or acceptable carrier. The preparation is any external preparation of pharmacy. The local irritation test researches to show that the ginkgo extractive is safe, is free from adverse reaction, such as skin irritation, allergy and the like. The trial result of patients with clinical infectious or anaphylactic skin diseases proves that the ginkgo extractive has obvious treating effect on various skin diseases, and the effective rate is 100%, and the ginkgo extractive is safe to use and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and therapeutic cosmetics, and specifically relates to the use of ginkgo extract in preparing external preparations for treating skin diseases. Background technique [0002] Dermatosis is one of the most common clinical diseases. Because most skin diseases have a long duration and are prone to repeated attacks, they bring suffering to patients and seriously affect their physical and mental health. Common skin diseases include inflammatory and allergic skin diseases. Inflammatory skin diseases (dermatitis) can be divided into infectious and non-infectious. Infectious skin diseases can be caused by bacteria, viruses, fungi and pathogens, such as impetigo, folliculitis, acne, herpes, tinea manuum, tinea corporis, Acariasis, scabies, etc.; non-infectious skin diseases are mostly allergic or allergic skin diseases, such as neurodermatitis, eczema, urticaria, sweat rash, pruritus, etc. The clinic...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P17/00
Inventor 王青雷红
Owner 王青
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