Method for preparing high-purity lycaconitine

A kind of high-purity technology of Niuline, which is applied in the field of preparation of high-purity Niuline, can solve the problems of small preparation volume and cumbersome operation, and achieve the effects of large preparation volume, high separation efficiency and improved recovery rate
CN102250002AInactive Publication Date: 2011-11-23NANJING ZELANG AGRI DEV
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
NANJING ZELANG AGRI DEV
Publication Date
2011-11-23
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention provides a method for preparing high-purity lycaconitine. The method provided by the invention comprises the following steps of: (1) preparing a solvent system with an upper phase which is a fixed phase and a lower phase which is a flowing phase; (2) filling a chromatograph column with the fixed phase and adjusting the rotating speed of a main machine to pump the flowing phase into the column; (3) dissolving 200-2000 mg of lycaconitine crude extract by using 20-100 ml of flowing phase; introducing the sample through a sample introducing valve and receiving a target component according to an ultraviolet map of a detector; and concentrating and crystallizing a flowing component to obtain a high-purity lycaconitine monomer. The lycaconitine prepared with the method provided by the invention can reach higher purity and the preparation method has the advantages of simplicity, high efficiency, low cost, easiness for reproduction and high separation and preparation capacity.
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Description

Technical field:

[0001] The invention relates to a method for separating and purifying the active ingredients of traditional Chinese medicines, in particular to a method for preparing high-purity Nitrine. Background technique:

[0002] Diterpene alkaloids are a class of polycyclic nitrogen-containing compounds with relatively complex structures. They have strong toxicity and extensive biological activities. research hotspot. Most of the diterpene alkaloids are distributed in the genus Aconitum and Delphinium. In my country, there are about 170 species of Aconitum and nearly 120 species of Delphinium. They are widely distributed all over the country, especially in the southwest region. The most concentrated, many of which have already been commonly used Chinese herbal medicines in our country. Diterpene alkaloids are not only active and toxic constituents of such plants, but are also considered to be their characteristic chemical constituents. It has been reported in the li...

Claims

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