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Therapeutic compositions and methods for treating chronic kidney disease associated with a metabolic imbalance

A technology for chronic kidney disease and composition, applied in the therapeutic composition and treatment field of chronic kidney disease accompanied by metabolic imbalance

Inactive Publication Date: 2011-11-23
理查德·J·约翰逊 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the researchers' surprise, the same treatment was ineffective in diabetic eNOSKO mice

Method used

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  • Therapeutic compositions and methods for treating chronic kidney disease associated with a metabolic imbalance
  • Therapeutic compositions and methods for treating chronic kidney disease associated with a metabolic imbalance
  • Therapeutic compositions and methods for treating chronic kidney disease associated with a metabolic imbalance

Examples

Experimental program
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Effect test

Embodiment Construction

[0085] Examples demonstrate the therapeutic value of combination therapy for outcomes related to diabetic nephropathy and / or metabolic symptoms

[0086] figure 1 ACE inhibitors were shown to effectively lower blood pressure in wild diabetic (DM) mice. figure 1 Shown are the therapeutic effects of no treatment (no TX), the ACE inhibitor enalapril (DM enalapril), and the ARB telmisartan (DM telmisartan). The ACE inhibitors enalapril and ARBs significantly reduced blood pressure in wild-type diabetic mice. figure 2 It shows that administration of ACE inhibitor (enalapril) and ARBs (telmisartan) can also improve mesangial enlargement (A) and glomerular type IV collagen deposition ( B). These are considered early changes in diabetic kidney disease.

[0087] In contrast, when ACE inhibitors and ARBs were administered to diabetic mice unable to produce endothelial nitric oxide, the effects of these drugs were surprisingly found to be minimal ( Figure 3-5 ). image 3 It was sh...

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PUM

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Abstract

Disclosed herein are compositions and methods for treating chronic kidney disease and / or a metabolic imbalance. Specifically exemplified herein are methods involving the coadministration of a RAS inhibitor with a conjunctive agent that improves endothelial NO or endothelial function. Also disclosed are methods of treating a patient exhibiting symptoms of a stage of chronic kidney disease and at least one symptom of a metabolic imbalance, such as one or more diagnostic criteria of the metabolic syndrome.

Description

[0001] related application [0002] This application claims priority to US Application Serial No. 61 / 106,602 (filed: October 19, 2008), which is hereby incorporated by reference in its entirety. Background technique [0003] Diabetes currently affects 8 percent of the U.S. population, and rates are rising. One of the most significant complications of diabetes is the development of kidney disease, which can progress to end-stage renal disease requiring dialysis or transplantation. Angiotensin transferase inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are currently used in the treatment of diabetic nephropathy, and the benefit is thought to be due in part to lowering blood pressure alone 1-4 . However, recent studies have shown that ACE inhibitors and ARBs are ineffective in delaying type 1 diabetic nephropathy, despite being effective in retarding retinopathy 5 . Other groups have also reported that ACE inhibitors do not work in pseudo-primary type 2 diabetes w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/40A61K31/435
CPCA61K45/06A61K31/435A61P13/12A61P19/06A61P3/04A61P3/06A61P43/00A61P9/12A61P3/10A61K2300/00
Inventor 理查德·J·约翰逊中川孝彦
Owner 理查德·J·约翰逊