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Improved traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of improved Zideng capsule preparations, can solve the problems of unpredictable synergistic effect, definite curative effect, untouched, etc., and achieve the effect of reducing drug cost, reducing raw material cost, and improving curative effect

Inactive Publication Date: 2011-12-14
楚雄老拨云堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The content disclosed in Chinese patent applications 200410079591.2 and 200510081576.6 is basically the prescription and preparation method in the Pharmacopoeia, and no new research content is introduced
[0006] Chinese patent 200610065050.3 did not change the prescription and preparation method in the Pharmacopoeia, but only added lactose, mannitol and dextrin on the auxiliary materials of the later preparation; Conventional pellet preparation
[0007] The composition of traditional Chinese medicine compound is complex, there are many potential active ingredients, and the synergistic effect is difficult to predict. It is usually difficult to determine the curative effect based on one of the compounds (otherwise, it can be developed into a western medicine)
Even if the raw materials are regulated by the "Chinese Pharmacopoeia", the potential active ingredients in them are very different. On the one hand, this causes the quality of different batches of drugs to be unstable; on the other hand, it also causes uncertainty in the curative effect.
Yet the developer of prior art has not touched the intention of these traditional Chinese medicine fundamental improvements, just made some improvements on conventional dosage form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Comparative example

[0043] According to the existing preparation method adopted by domestic pharmaceutical factories, its main difference from Examples 2-4 has two points: 1, choose the good quality Erigeron breviscapine purchased in the market, wherein the content of scutellarin is detected by HPLC to reach 1.30~ Between 1.80%; take Panax notoginseng and purple salvia miltiorrhiza respectively, crush them through an 80-mesh sieve, take 150 kg of notoginseng and 150 kg of fine powder of purple salvia miltiorrhiza respectively, mix them evenly, and sterilize at 120°C for 15 minutes.

[0044] Get licorice, crush it through a 20-mesh sieve, get 100 kg of licorice powder, and set aside. Take pueraria root, purple salvia miltiorrhiza and scutellaria sage, crush through a 20-mesh sieve, take 450 kg of scutellaria scutellaria, 200 kg of pueraria lobata and 300 kg of purple sage root and mix evenly, add 6000 liters of 70% (weight) ethanol at 70 °C Heat to reflux f...

Embodiment 2

[0047] Example 2 Preparation of the improved Zideng Capsule 1

[0048] Erigeron breviscapine was purchased and selected from the market, and detected by HPLC, the content of scutellarin in it was 0.82%, and it was set aside. Take Panax notoginseng and purple salvia miltiorrhiza respectively, crush them through an 80-mesh sieve, take 150 kg of notoginseng and 150 kg of purple salvia miltiorrhiza as fine powders, mix them evenly, and pass them through a cobalt 60 irradiation sterilizer to sterilize them at room temperature for later use. Get licorice, crush it through a 20-mesh sieve, get 100 kg of licorice powder, and set aside.

[0049] Take Pueraria Radix and Purple Salvia and the above-mentioned scutellarin content of scutellaria scutellaria, crushed through a 20-mesh sieve, respectively took 450 kilograms of scutellaria scutellaria, 200 kilograms of Pueraria lobata and 300 kilograms of purple salvia miltiorrhiza, mixed evenly, and added 6000 liters of 70% ( Weight) ethan...

Embodiment 3

[0053] Example 3 Preparation of the improved Zideng Capsule 2

[0054] Erigeron breviscapine was purchased and selected from the market, and detected by HPLC, the content of scutellarin in it was 0.45%, and it was set aside. Take Panax notoginseng and purple salvia miltiorrhiza respectively, crush them through an 80-mesh sieve, take 150 kg of notoginseng and 150 kg of purple salvia miltiorrhiza as fine powders, mix them evenly, and pass them through a cobalt 60 irradiation sterilizer to sterilize them at room temperature for later use. Take licorice, crush it through a 10-mesh sieve, take 100 kg of licorice coarse powder, and set aside.

[0055] Take Pueraria lanceolata, purple salvia miltiorrhiza and the scutellaria scutellarin content above, crush through a 10-mesh sieve, take 450 kg of scutellaria scutellaria, 200 kg of pueraria lobata and 300 kg of purple salvia miltiorrhiza and mix evenly, add 5800 liters of 70% ( Weight) ethanol was heated to reflux at 65°C for 1 hour...

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PUM

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Abstract

The invention provides an improved Chinese medicinal composition. The improved Chinese medicinal composition is made from erigeron breviscapine serving as a low-cost raw material. Although the contents of certain index compounds are lowered, the final curative effects on most adaptation diseases are improved. The invention further provides a preparation method, application and the like of the Chinese medicinal composition.

Description

technical field [0001] The present invention belongs to the field of traditional Chinese medicine. Specifically, the present invention provides improved Zideng capsule preparations, which are made from low-cost Erigeron breviscapus raw materials. Although the index compounds therein are reduced, the final curative effect is more effective than most indications. Both have improved. Background technique [0002] Zideng Jiaonang (Zideng Jiaonang) is a preparation of traditional medicine of the Yi nationality. It can be taken orally to treat "Le Bei Nuo, Wu Ge Qi Ge Nuo", that is, it has the effects of warming the meridian and dispelling cold, nourishing Qi and activating blood, relieving spasm and relieving pain. It is mainly used for Treat cervical spondylosis. The drug preparation has been included in the standard WS3-10412 (ZD0412)-2002 in the early years and included in the "Chinese Pharmacopoeia", specifically: [0003] [Prescription] Erigeron breviscapitalis 450g, purpl...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P19/08A61P29/00
Inventor 殷亦坚
Owner 楚雄老拨云堂药业有限公司
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