Gene for encoding HPV (human papilloma virus) 6-type L2N120E7E6 fusion protein, expression vectors, method, bacteria strain and application

A technology of L2N120E7E6 and fusion protein, applied in the field of medical biology, can solve problems affecting the effective presentation of E7 protein and affecting hydrolysis
CN102286104BActive Publication Date: 2013-10-16STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
Publication Date
2013-10-16

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Abstract

The invention provides a gene for encoding HPV (human papilloma virus) 6-type L2N120E7E6 fusion protein, expression vectors, a method, a bacteria strain and an application. The invention is characterized in that prokaryotic expression vectors are utilized to fuse HPV 6-type L2N-end 120 amino acids, E7 proteins and E6 proteins, and constructing the encoded gene according to the amino acid of the fusion protein. In the invention, the gene for encoding the HPV 6-type L2N120E7E6 fusion proteins is successfully designed and the expression vectors and the transformation bacteria strain of the high-expression HPV 6-type L2N120E7E6 fusion proteins are successfully constructed; and in the fusion proteins, the immunogenicity is strong, the immunoreaction of specific T cells can be induced, the tumor forming time of mice can be obviously delayed, and the growth of the tumors of 20% mice is completely restrained. The invention can be used for preventing and treating HPV 6-type infection and relevant diseases, such as genital wart.
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Description

technical field

[0001] The invention belongs to the field of medical biotechnology. Specifically, the present invention relates to a gene expressing human papillomavirus (HPV) type 6 L2N120E7E6 fusion protein, expression vector, method and immunotherapy and prevention application. Background technique

[0002] Genital warts (Genital Wart, GW) are one of the most common sexually transmitted diseases in the world. Although GW generally does not lead to death, it can cause psychological shadows in patients and bring about expensive treatment costs. The current treatment methods for GW mainly include: antiproliferative drugs, cryotherapy, destructive therapy, immunomodulators, etc. Incompatibility and recurrence of warts caused by these methods are very common, and the disease has not been cured fundamentally. For effective immunoprevention and treatment of GW methods.

[0003] The close relationship between GW and human papillomavirus (Human Papillomavirus, HPV) infection ha...

Claims

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