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Combination antibody kit for risk assessment of postoperative recurrence of primary hepatocellular carcinoma

A technology for hepatocellular carcinoma and a kit, applied in the biological field, can solve problems such as low efficacy, and achieve the effects of simple detection process, mature experimental method, and objective and accurate results.

Inactive Publication Date: 2011-12-28
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since traditional clinicopathological diagnosis or a single molecular marker is less effective in judging the prognosis of patients after surgery, the kits used in combination with multiple molecular markers will be a new direction of research and development

Method used

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  • Combination antibody kit for risk assessment of postoperative recurrence of primary hepatocellular carcinoma
  • Combination antibody kit for risk assessment of postoperative recurrence of primary hepatocellular carcinoma
  • Combination antibody kit for risk assessment of postoperative recurrence of primary hepatocellular carcinoma

Examples

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Embodiment 1

[0026] A combined antibody kit for risk assessment of postoperative recurrence of primary hepatocellular carcinoma, which includes 8 protein molecules detected by primary antibodies: CD80, B7-DC, HLA-DR, FasL, Bcl-2 , CK19, Ki-67 and Cyclin D1, clear positive signals can be detected in paraffin sections of liver cancer tissues by using 8 kinds of primary antibodies (such as figure 1 shown), the specific steps include the following three parts:

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Abstract

The invention discloses a multi-antibody detection kit used in postoperative recurrence risk assessment after a resection operation is performed on a primary hepatocellular carcinoma patient. The kit comprises 8 immunohistochemical antibodies used for paraffin sections. The invention also discloses a method for determining postoperative recurrence risk of a liver cancer patient by using the kit. The prediction effect provided by the invention is superior to an existing clinical index. The kit and the method provided by the invention have characteristics of objective, convenient, direct, and repeatable. The kit can be used in the predictions of recurrence and death after clinical liver cancer resection operations. The kit assists in screening liver cancer patients with high postoperative recurrence risk. Therefore, appropriate auxiliary treatments can be directed, recurrence can be effectively reduced, and patient survival time can be prolonged.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a detection kit for assessing the recurrence risk of patients with hepatocellular carcinoma after resection. Background technique [0002] Primary hepatocellular carcinoma (liver cancer for short) is a common malignant tumor with the sixth and third highest morbidity and mortality rates, and China is a high-incidence area for liver cancer. In recent years, the incidence of liver cancer has a rising trend, seriously endangering human health and life safety. HCC is prone to vascular invasion and metastasis, which is the main reason for its high recurrence rate and poor prognosis. Therefore, effective prediction of postoperative recurrence in patients will help to select the appropriate treatment population and methods, and provide strong support for effective diagnosis and treatment. Since traditional clinicopathological diagnosis or a single molecular marker is less effective in jud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
Inventor 郑利民许静丁童何琪余杏娟贾卫华石明
Owner SUN YAT SEN UNIV CANCER CENT
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