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A kind of racecadotril dry suspension

A technology for racecadotril and dry suspension, which is applied to the digestive system, medical preparations of inactive ingredients, organic active ingredients, etc., can solve problems such as bad taste, and achieve easy industrial production and good sedimentation volume ratio. , The effect of solving the problem of bad taste

Active Publication Date: 2017-04-12
HAINAN HONZ PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a kind of racecadotril dry suspension, which not only has good pharmaceutical effects such as stability, but also through specific correctives, the racecadotril dry suspension of the present invention not only solves the problem of The problem of bad taste, but also surprisingly found that it has the effect of fast onset and high bioavailability, and it is better used in clinical practice, especially as a pediatric pharmaceutical preparation

Method used

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  • A kind of racecadotril dry suspension
  • A kind of racecadotril dry suspension
  • A kind of racecadotril dry suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Make a prescription (calculated according to 1000 bags)

[0035]

[0036] 2. Preparation method

[0037] ① Mix the ratio of racecadotril and mangosteen through 200 sieves, and 80 sieves of carmellose sodium, sucrose, poloxamer, and micronized silica gel respectively, and set aside.

[0038] ② Mix the full amount of racecadotril and mannitol mixture, carmellose sodium and poloxamer in equal amounts and mix evenly, then mix evenly with sucrose, use ethanol as a wetting agent, fully moisten and evenly, pass 20 Granulate with a mesh sieve, dry at 50°C, pass through a 40-mesh sieve for granulation, and obtain Granule A.

[0039] ③Mix granule A with the full amount of micro-powdered silica gel in the prescription to get granule B, and set aside.

[0040] ④Take an appropriate amount of the above-mentioned granules, and measure the water content and percentage content. Control the water content below 2%, and the content is between 95% and 105%.

[0041] ⑤Packing and p...

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PUM

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Abstract

The invention provides a racecadotril suspension, which is composed by the following ingredients: 1 part of racecadotril, 1-3 part(s) of mannitol, 5-9 parts of carboxymethylcellulose odium, 150-200 parts of cane sugar, 1-6 part(s) of ploxamer and 1-6 part(s) of aerosil. The racecadotril suspension has well stability and other pharmaceutical effects, because the flavoring agent is utilized, the racecadotril suspension not only solves the bad taste problem, but also surprisingly has the quick effect and high bioavailability, is better applied in clinic, and is particularly used as pediatrics pharmaceutical preparations.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a racecadotril dry suspension. It belongs to the field of pharmaceutical preparations. Background technique [0002] As the first neprilysin inhibitor for diarrhea, racecadotril is highly effective, fast-acting, and has a high therapeutic index. It has no adverse reactions and does not cause constipation, so it is by far the most ideal antidiarrheal drug, and the market potential is very huge. [0003] Racecadotril is rapidly absorbed after oral administration, first distributed in the gastrointestinal tract, does not pass through the blood-brain barrier, and is rapidly decomposed into its active metabolite Thiorphan: (R, S)-N-(1-oxo-2- mercaptomethyl-3-phenylpropylglycine), then converted to inactive metabolites, which are eliminated through the kidneys, feces and lungs. After administration of 100mg, the activity of inhibiting serum neprilysin appears within 30 minutes, the bi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/265A61K47/38A61P1/12
Inventor 王稳奇洪丽萍凌日金洪江游
Owner HAINAN HONZ PHARMA
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