Nifedipine medicine composition and preparation method thereof

Abstract

The invention discloses a nifedipine medicine composition and a preparation method thereof. The nifedipine medicine composition contains nifedipine, hydroxymethyl propyl cellulose and microcrystalline cellulose. The hydroxymethyl propyl cellulose is used as slow-releasing framework material; the weight ratio of the nifedipine and the hydroxymethyl propyl cellulose is 2:1-1:1; and the weight ratio of the nifedipine and the microcrystalline cellulose is 1:4-1:3; and lactose, starch, calcium hydrophosphate and glucose can be also added. The method for preparing the nifedipine medicine composition comprises the following steps of: (1) crushing and screening; (2) drying; and (3) tabletting. According to the invention, the dissolution rate of the nifedipine in the water can be increased, the coronary arteries in the normal blood supply area and the ischemic area are relaxed while the absorption rate of the nifedipine in the body is increased so that coronarospasm and is released and prevented and myocardial contraction is inhibited; myocardial oxygen consumption is reduced; the peripheral resistance is released; after load of heart is reduced; sinus node function and atrioventricular conduction of the isolated heart are slowed down; and the nifedipine medicine composition is applicable to variant angina pectoris, unstable angina pectoris and chronic stable angina pectoris.

Description

technical field [0001] The invention belongs to the field of new medicine technology, in particular to a nifedipine pharmaceutical composition and a preparation method thereof. Background technique [0002] Nifedipine is a dihydropyridine calcium ion channel antagonist, which is suitable for various types of hypertension and has a good effect on intractable and severe hypertension. Because it can reduce afterload, it also has good curative effect on refractory congestive heart failure and is suitable for long-term use. Nifedipine has the strongest effect on expanding coronary arteries and peripheral arteries, and has a significant effect on inhibiting vasospasm. It is the drug of choice for variant angina. It is clinically applicable to the prevention and treatment of angina pectoris caused by coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm. In addition, it is also suitable for patients with angina pectoris suf...

AI Technical Summary

Problems solved by technology

[0003] Common preparations of nifedipine reflexively cause adverse reactions such as increased heart rate, activation of the sympathetic nervous system, and adverse effects on the control of myocardial ischemia and heart failure, and require frequent administration, so they are not suitable for long-term treatment of hypertension, nor Suitable for hypertensive emergencies, acute myocardial infarction or acute coronary syndrome, making it difficult to meet the patient's medication needs