Nifedipine medicine composition and preparation method thereof

A technology of nifedipine and a composition, applied in the new field of medicine, can solve the problems of being unsuitable for acute coronary syndrome, unsuitable for long-term treatment of hypertension, difficult to meet the demand for medication, etc. Conduction, relief and prevention of coronary spasm, and reduction of cardiac oxygen consumption

Inactive Publication Date: 2012-03-14
JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Common preparations of nifedipine reflexively cause adverse reactions such as increased heart rate, activation of the sympathetic nervous system, and adverse effects on the control of myocardial ischemia and heart failure, and require ...

Method used

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Examples

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Embodiment Construction

[0014] A kind of nifedipine pharmaceutical composition of the present invention and its preparation method are illustrated below in conjunction with the examples.

[0015] A nifedipine pharmaceutical composition contains nifedipine, hypromellose and microcrystalline cellulose. The weight ratio of nifedipine to hydroxypropyl methylcellulose is 2:1, the weight ratio of nifedipine to microcrystalline cellulose is 1:3, and lactose, starch, calcium hydrogen phosphate, and glucose are added.

[0016] A method for preparing the above-mentioned nifedipine pharmaceutical composition, comprising the following steps:

[0017] (1) Crushing and sieving: take nifedipine, hydroxypropyl methylcellulose, microcrystalline cellulose, lactose, starch, calcium hydrogen phosphate, glucose, mix the raw materials, pass through a 40-mesh sieve, and mix evenly;

[0018] (2) Drying: Use 2% hydroxypropyl methylcellulose as a soft material, pass through a 16-mesh nylon sieve to granulate, dry in an oven ...

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PUM

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Abstract

The invention discloses a nifedipine medicine composition and a preparation method thereof. The nifedipine medicine composition contains nifedipine, hydroxymethyl propyl cellulose and microcrystalline cellulose. The hydroxymethyl propyl cellulose is used as slow-releasing framework material; the weight ratio of the nifedipine and the hydroxymethyl propyl cellulose is 2:1-1:1; and the weight ratio of the nifedipine and the microcrystalline cellulose is 1:4-1:3; and lactose, starch, calcium hydrophosphate and glucose can be also added. The method for preparing the nifedipine medicine composition comprises the following steps of: (1) crushing and screening; (2) drying; and (3) tabletting. According to the invention, the dissolution rate of the nifedipine in the water can be increased, the coronary arteries in the normal blood supply area and the ischemic area are relaxed while the absorption rate of the nifedipine in the body is increased so that coronarospasm and is released and prevented and myocardial contraction is inhibited; myocardial oxygen consumption is reduced; the peripheral resistance is released; after load of heart is reduced; sinus node function and atrioventricular conduction of the isolated heart are slowed down; and the nifedipine medicine composition is applicable to variant angina pectoris, unstable angina pectoris and chronic stable angina pectoris.

Description

technical field [0001] The invention belongs to the field of new medicine technology, in particular to a nifedipine pharmaceutical composition and a preparation method thereof. Background technique [0002] Nifedipine is a dihydropyridine calcium ion channel antagonist, which is suitable for various types of hypertension and has a good effect on intractable and severe hypertension. Because it can reduce afterload, it also has good curative effect on refractory congestive heart failure and is suitable for long-term use. Nifedipine has the strongest effect on expanding coronary arteries and peripheral arteries, and has a significant effect on inhibiting vasospasm. It is the drug of choice for variant angina. It is clinically applicable to the prevention and treatment of angina pectoris caused by coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm. In addition, it is also suitable for patients with angina pectoris suf...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K47/38A61P9/10
Inventor 刘德胜
Owner JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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