Enterovirus 71 (EV71) monoclonal antibody and application thereof

A monoclonal antibody and virus technology, applied in the field of virus immunity biomedicine, can solve the problems of high test cost, long detection time, difficult to popularize and use, etc., and achieve the effect of strong guiding significance, high neutralization activity and so on.
CN102409028AActive Publication Date: 2012-04-11SINOVAC BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SINOVAC BIOTECH
Publication Date
2012-04-11

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Abstract

The invention provides an enterovirus 71 (EV71) monoclonal antibody and an application thereof. The monoclonal antibody is derived from an EV71 hybrid tumor cell strain, which has a preservation number of CGMCC (China General Microbiological Culture Collection) No.5330. The monoclonal antibody and related reagents thereof have important significance in promoting the treatment and research of severe cases and death cases caused by EV71 in China, and have extremely important value in further promoting clinical research, epidemic development and passive treatment of EV71.
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Description

technical field

[0001] The invention relates to the field of virus immune biomedicine, in particular to an enterovirus 71 monoclonal antibody and its application. Background technique

[0002] Hand, foot and mouth disease (Hand, foot and mouth diseases, HFMD) is a fecal-oral disease that is widely prevalent in the world, and it has been reported in most parts of the world. For a long time, mild hand, foot and mouth disease broke out periodically all over the world. The disease was first reported in New Zealand in 1957, the Coxsackie virus was isolated for the first time in 1958, and the name of hand, foot and mouth disease was proposed in 1959. In 1969, enterovirus 71 (EV71 virus) was isolated from stool samples of infants with central nervous system diseases in the United States, and the virus was first confirmed. The interval between the prevalence of HFMD is 2-3 years. The early pathogens were mainly Cox A16, and later EV71 and Cox A16 appeared alternately, becoming the...

Claims

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