Coxsackie virus A16 type virus-like particle vaccine

A coxsackie virus, A16 technology, applied in the field of biotechnology and biomedicine, can solve problems such as an ideal vaccine without coxsackie virus
CN102465144AInactive Publication Date: 2012-05-23INST PASTEUR OF SHANGHAI CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST PASTEUR OF SHANGHAI CHINESE ACADEMY OF SCI
Publication Date
2012-05-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a coxsackie virus A16 type virus-like particle vaccine. The inventor fortuitously finds that proteins which have better spatial configurations and are suitably cut can be obtained by expressing P1 protein of CVA16 and 3CD protein of CVA16 by infecting insect cells with rhabdovirus. The proteins can be automatically assembled into a virus-like particle which has high immunogenicity.
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Description

technical field

[0001] The invention belongs to the fields of biotechnology and biomedicine; more specifically, the invention relates to a Coxsackievirus A16 virus-like particle vaccine. Background technique

[0002] Hand, foot and mouth disease is a common disease in children, and there is still no effective vaccine and treatment. Coxsackievirus A16 (CVA16) and human enterovirus 71 (EV71) are the two most important pathogens of hand, foot and mouth disease, belonging to the family Picornaviridae Enterovirus, single-stranded positive-sense RNA virus with a genome of about 7400bp (Xu , J., Y. Qian, S. Wang, J.M. Serrano, W. Li, Z. Huang, and S. Lu. 2010. EV71: anemerging infectious disease vaccine target in the Far East Vaccine 28: 3516-21 and Zhang, Y ., D. Wang, D. Yan, S. Zhu, J. Liu, H. Wang, S. Zhao, D. Yu, L. Nan, J. An, L. Chen, H. An, A. Xu, and W. Xu. 2010. Molecular evidence of persistentepidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, ...

Claims

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