Application of honokiol in pharmacy, and medicine used for treating type II diabetes mellitus

A technology of honokiol and diabetes, applied in the application field of honokiol, which can solve problems such as adverse reactions, inability to reduce obesity, and serious side effects of the human body

Inactive Publication Date: 2012-06-27
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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Problems solved by technology

[0004] The present invention aims to provide a kind of application of honokiol in pharmacy and the medicine for treating type Ⅱ diabetes, to solve the problem that the medicine for treating diabetes in the prior art has serious side effects on human body or can cause other adverse reactions, and in reducing While blood sugar does not reduce obesity technical problems

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  • Application of honokiol in pharmacy, and medicine used for treating type II diabetes mellitus
  • Application of honokiol in pharmacy, and medicine used for treating type II diabetes mellitus

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Embodiment Construction

[0016] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other. The present invention will be described in detail below in combination with experimental data.

[0017] The present invention first proves that honokiol is a PPARα / γ dual agonist through in vitro cell line screening. On this basis, through the internationally recognized spontaneous KKA y Type 2 diabetes mouse model, demonstrating in vivo activity. KKA y Type Ⅱ diabetes mouse model is currently recognized as the best animal model for screening and treatment of type Ⅱ diabetes in the world. The present invention uses the animal model to conduct main pharmacodynamic studies, and the results show that the honokiol has the effects of lowering blood sugar and reducing body weight. Therefore, the honokiol can be used in the preparation of medicines for treating type Ⅱ diabetes and the preparation of medicines for...

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Abstract

The invention discloses an application of honokiol in pharmacy, and a medicine used for treating type II diabetes mellitus. The invention provides an application of honokiol in preparing medicines used for treating type II diabetes mellitus, obesity caused by lipid metabolism disorder, or diseases related to insulin resistance. Honokiol is a PPAR alpha/gamma dual agonist. Therefore, honokiol can be used for ameliorating insulin resistance and reducing blood sugar, and honokiol can also be used for ameliorating lipid metabolism disorder and reducing weight.

Description

technical field [0001] The invention relates to the application of honokiol, in particular to the application of honokiol in pharmacy and the medicine for treating type Ⅱ diabetes. Background technique [0002] With the development of social economy and the improvement of material living standards, the incidence of obesity has increased significantly. During the 10 years from 1992 to 2002, the overweight rate and obesity rate of Chinese residents increased by 38.6% and 80.6% respectively. In 2002, the incidence of obesity in my country was close to 25%, and it showed a rapid growth trend. Obesity is associated with the onset of various diseases such as type 2 diabetes. [0003] At present, the pathological core of type 2 diabetes caused by obesity is insulin resistance, and improving insulin resistance can effectively reduce blood sugar in patients with type 2 diabetes. Although drugs based on improving insulin resistance to treat type Ⅱ diabetes have been used clinically...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P3/10A61P3/04A61P5/50
Inventor 王建农
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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