Lung targeting preparation of curcumin class compound as well as preparation method and application thereof

A technology of curcumin and lung targeting, which is applied in the direction of non-active ingredients of polymer compounds, drug combinations, and pharmaceutical formulas, and can solve the problems of drug waste, non-targeting, and increased doses, etc.

Inactive Publication Date: 2012-06-27
SHANGHAI JIAO TONG UNIV
View PDF8 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after these preparations are administered, the drug is evenly distributed in the blood and tissues, and there is no targeting. If the drug concentration in the target area is to be increased, the dosage must be increased, which not only causes waste of the drug, but also increases the toxic and side effects of the drug and the effect of the drug. residues in the body

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lung targeting preparation of curcumin class compound as well as preparation method and application thereof
  • Lung targeting preparation of curcumin class compound as well as preparation method and application thereof
  • Lung targeting preparation of curcumin class compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 curcumin injection

[0058]The concentration of curcumin is 50 mg / ml, Pluronic F68 and polyoxyethylene hydrogenated castor oil are selected as surface active substances, the total concentration is 1000 mg / ml, and medicinal absolute ethanol is used as a solvent to prepare a curcumin concentrated solution. The specific preparation method is as follows: 4 g of Pluronic F68 and 1 g of polyoxyethylene hydrogenated castor oil are dissolved in medicinal anhydrous ethanol, heated to fully dissolve, and cooled to 5 ml. Add 250mg of curcumin, and dissolve it ultrasonically in a water bath to obtain an orange transparent drug concentrated solution. Store away from light and low temperature. Before use, according to the ratio of 1:10, water was added into the concentrated solution, mixed evenly while adding, and finally the curcumin injection with a concentration of 5 mg / ml and an average particle size of 168 nm was obtained.

[0059] Take 20ml of the prepared 5mg / ml...

Embodiment 2

[0060] Embodiment 2 curcumin injection

[0061] Add 20mg of curcumin and 500mg of Pluronic F68 into 1ml of medicinal absolute ethanol, heat and dissolve in a closed test tube to obtain an orange transparent concentrated drug solution. Store away from light and low temperature. Before use, according to the ratio of 1:10, it was added dropwise to 5% glucose injection, and mixed evenly while adding, to obtain curcumin injection with a final concentration of 2mg / ml and an average particle diameter of 190nm.

Embodiment 3

[0062] Embodiment 3 curcumin injection

[0063] The specific preparation method is as follows: 5 mg of curcumin, 100 mg of phospholipid and 100 mg of pluronic F68 are dissolved in 1 ml of DMSO-water (1:1, v / v) mixed solution to obtain a clear solution. Store away from light and low temperature. Before use, according to the ratio of 1:10, add dropwise into sterile water for injection, and mix evenly while adding. Obtaining concentration is the curcumin injection of 0.5mg / ml. The average particle diameter is 180nm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Concentrationaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention relates to a lung targeting preparation of curcumin and / or an analog thereof as well as a preparation method and application thereof. The medicine preparation contains a surface active substance and curcumin and / or an analog thereof; the curcumin and / or the analog are(is) loaded in a micell-shaped self-assembly structure formed by the surface active substance; and the lung targeting preparation of the curcumin and / or the analog thereof has the advantages of high medicine carrying quantity and favorable safety and stability, and can be used for intravenous injection. After the intravenous injection of the lung targeting preparation of the curcumin and / or the analog thereof is carried out, the curcumin can be concentrated at the tissue of the lung, so that the blood concentration of the lung is increased, the curative effect of medicine is enhanced, and the dosage of the medicine is obviously lowered.

Description

technical field [0001] The present invention relates to a lung-targeting preparation of curcumin and its analogs and its preparation method and application, in particular to a preparation method and application of curcumin and its analog lung-targeting preparation for preventing and treating acute lung injury, belonging to Pharmaceutical formulations and their fields of application. Background technique [0002] Curcumin and its analogues are active ingredients isolated from the roots of turmeric plants such as turmeric, turmeric and zedoary, including curcumin, demethoxycurcumin and bis-nor Bisdemethoxycurcumin (bisdemethoxycurcumin) has various pharmacological effects such as anti-tumor, anti-inflammatory, anti-HIV, antibacterial, anti-oxidation, etc., and has low toxicity, and has good potential for clinical application, and has received extensive attention at home and abroad (Cui Jing et al., Research progress of curcumin, Zhongnan Pharmacy, 3(2): 108-111, 2005). Their...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/12A61K47/44A61K47/42A61K47/34A61K47/24A61P11/00
Inventor 魏晓慧孙加源徐宇虹韩宝惠
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap