Calcium-ion antagonist orally disintegrating tablet and preparation method thereof
A technology for calcium ion antagonist and oral disintegrating tablet, applied in the field of calcium ion antagonist oral disintegrating tablet and preparation thereof, can solve the problems of gritty feeling, affecting patient's taste and compliance, slow disintegration of preparations, etc.
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Embodiment 1
[0155] The preparation formula of the present invention is made up of following components:
[0156] Amlodipine besylate 6.93g
[0157] Glycine 5.60g
[0158] Pullulan 7.60g
[0159] Konjac Gum 0.60g
[0160] Aspartame 1.00g
[0161] Mint essence 0.20g
[0162] Purified water 178.07g
[0163] A total of 1000 pieces were made.
[0164] The specific preparation method is as follows: Amlodipine besylate, glycine, pullulan, aspartame, and peppermint essence are added to the fully dissolved konjac gum solution, and mixed to become a uniform solution; After degassing, pour it into the mold accurately; pre-freeze at -40°C to -170°C for 1 to 60 minutes, then transfer it to a freeze dryer, under the conditions of 0.01mbar to 10mbar and -30°C to 30°C Freeze-dry for 1-10 hours to obtain the orally disintegrating amlodipine besylate tablet of the present invention; after the pre-freezing step in the above method, a step of ice crystal incubation can also be added before being trans...
Embodiment 2
[0166] The preparation formula of the present invention is made up of following components:
[0167] Amlodipine besylate 6.93g
[0168] Mannitol 5.60g
[0169] Pullulan 7.60g
[0170] Konjac Gum 0.60g
[0171] Aspartame 1.00g
[0172] Mint essence 0.20g
[0173] Purified water 178.07g
[0174] A total of 1000 pieces were made.
[0175] The specific preparation method is as follows: Amlodipine besylate, mannitol, pullulan, aspartame, and peppermint essence are added to the fully dissolved konjac gum solution, and mixed to become a homogeneous solution; The preparation method is the same as in Example 1.
Embodiment 3
[0177] The preparation formula of the present invention is made up of following components:
[0178] Amlodipine besylate 6.93g
[0179] Glycine 3.00g
[0180] Mannitol 2.00g
[0181] Pullulan 7.00g
[0182] Xanthan gum 0.10g
[0183] Acesulfame K 1.20g
[0184] Mint essence 0.20g
[0185] Purified water 179.57g
[0186] A total of 1000 pieces were made.
[0187] The specific preparation method is as follows: add amlodipine besylate, glycine, mannitol, pullulan, acesulfame potassium, and mint essence to the fully dissolved xanthan gum solution, and mix to form a uniform solution; The following preparation method is the same as in Example 1.
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