Method for preparing rosiglitazone tartrate
A technology of tartrate and diketone, which is applied in the field of preparation of tartrate Roger and novel thiazolidinedione derivatives, can solve the problems of high price, high price, limited clinical application and the like, and achieves short reaction time, fast onset, The effect of good pharmaceutical properties
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[0012] Example: Preparation of 5-[4-[2-Methyl-N-(2-pyridyl)amino)ethoxy]thiazolidine-2,4-dione tartrate
[0013] Add 12g of 5-[4-[2-methyl-N-(2-pyridyl)amino)ethoxy]thiazolidine-2,4-dione into a 500mL reaction flask, and then add 350mL of absolute ethanol, Stir until completely dissolved, heat to reflux until the system is clear, add 5.3 g of tartaric acid, and continue to reflux and stir for 1 h. After the reaction is completed, cool to room temperature naturally, and a white solid precipitated, filtered, washed with absolute ethanol (10 mL×3), and the product was air-dried at 60°C under normal pressure for 12 hours. The yield was 95%. IR (KBr): 3453, 3342, 3253, 3070, 2983, 2929, 2896, 2783, 1751, 1697, 1629, 1540, 1512, 1461, 1413, 1351, 1287, 1234, 1174, 1133, 1075, 941, 921 , 901, 838, 750, 721, 673, 620, 599, 556, 524, 507 cm -1 ; 1 H NMR (400 MHz, DMSO): δ 12.3 (s, 2H), 8.08 (d, J = 3.6 Hz, 1H), 7.50 (m, 1H), 7.13 (d, J = 8.4 Hz, 2H), 6.87 (d, J = 8.4 Hz, 2H), 6.64 (...
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