Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing rosiglitazone tartrate

A technology of tartrate and diketone, which is applied in the field of preparation of tartrate Roger and novel thiazolidinedione derivatives, can solve the problems of high price, high price, limited clinical application and the like, and achieves short reaction time, fast onset, The effect of good pharmaceutical properties

Active Publication Date: 2012-07-04
KAIFENG PHARMA GRP +1
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the rosiglitazone currently used in China is mostly imported, the price is relatively high, and the price is expensive, which is unbearable for ordinary patients, so that the clinical application is limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing rosiglitazone tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0012] Example: Preparation of 5-[4-[2-Methyl-N-(2-pyridyl)amino)ethoxy]thiazolidine-2,4-dione tartrate

[0013] Add 12g of 5-[4-[2-methyl-N-(2-pyridyl)amino)ethoxy]thiazolidine-2,4-dione into a 500mL reaction flask, and then add 350mL of absolute ethanol, Stir until completely dissolved, heat to reflux until the system is clear, add 5.3 g of tartaric acid, and continue to reflux and stir for 1 h. After the reaction is completed, cool to room temperature naturally, and a white solid precipitated, filtered, washed with absolute ethanol (10 mL×3), and the product was air-dried at 60°C under normal pressure for 12 hours. The yield was 95%. IR (KBr): 3453, 3342, 3253, 3070, 2983, 2929, 2896, 2783, 1751, 1697, 1629, 1540, 1512, 1461, 1413, 1351, 1287, 1234, 1174, 1133, 1075, 941, 921 , 901, 838, 750, 721, 673, 620, 599, 556, 524, 507 cm -1 ; 1 H NMR (400 MHz, DMSO): δ 12.3 (s, 2H), 8.08 (d, J = 3.6 Hz, 1H), 7.50 (m, 1H), 7.13 (d, J = 8.4 Hz, 2H), 6.87 (d, J = 8.4 Hz, 2H), 6.64 (...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing rosiglitazone tartrate, relates to a method for preparing a novel medicinal compound, namely 5-[4-[2-methyl-N-(2-pyridyl) amino] ethoxy] thiazolidine-2,4-diketone tartrate, and belongs to the field of medicinal chemistry. The method comprises the following steps of: adding 5-[4-[2-methyl-N-(2-pyridyl) amino] ethoxy] thiazolidine-2,4-diketone into a polar solvent, adding tartaric acid with heating to dissolve the 5-[4-[2-methyl-N-(2-pyridyl) amino] ethoxy] thiazolidine-2,4-diketone, refluxing, cooling to room temperature after the reaction is finished, filtering, drying, and thus obtaining a product. The method is high in yield, short in reaction time, very simple in post treatment and convenient for industrialized production. The prepared compound can be used for treating type II diabetes and multiple diabetic complications, and is high in bioavailability and quick in response; and the pharmacokinetics of the compound is not affected by age.

Description

technical field [0001] The present invention relates to a kind of preparation method of novel thiazolidinedione derivative, especially relates to tartrate rogergol [0002] The invention discloses a preparation method of ketone, which belongs to the field of medicinal chemistry. Background technique [0003] Diabetes is a common and frequently-occurring disease. The number of patients is increasing rapidly with the changes in people's lifestyles and the aging of the population. Once the disease occurs, it is necessary to take medicine for life; the prevalence, disability and mortality of diabetes And the degree of overall health hazard has ranked third among non-communicable diseases, becoming the third largest disease that seriously threatens human health after cardiovascular and cerebrovascular diseases and tumors. Diabetes can also induce a variety of diseases, seriously endanger people's health and life, and bring a heavy economic burden to society. Therefore, the rese...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D417/12C07C59/255C07C51/41A61P3/10
Inventor 吴亚朱松林朱成功周振陈水库
Owner KAIFENG PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com