Photon counting-type dynamic diffusion fluorescence tomography method and device

A photon counting and dynamic diffusion technology, applied in fluorescence/phosphorescence, diagnosis, diagnostic recording/measurement, etc., can solve the problems of long integration time, short test time, low spatial sampling density, etc., and achieve high sampling density and wide measurement range. Effect

Active Publication Date: 2012-07-11
TIANJIN UNIV
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Problems solved by technology

[0005] For diffuse fluorescence tomography, because the fluorescence signal is relatively weak, CCD technology requires a long integration time to obtain a good signal-to-noise ratio; discrete multi-channel measurement technology has a short test time but low spatial sampling density and low image resolution. high

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  • Photon counting-type dynamic diffusion fluorescence tomography method and device
  • Photon counting-type dynamic diffusion fluorescence tomography method and device
  • Photon counting-type dynamic diffusion fluorescence tomography method and device

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Embodiment Construction

[0036] The technical scheme adopted by the present invention is: a photon counting type dynamic diffusion fluorescence tomography imaging system, comprising:

[0037] The light source system for exciting fluorescence includes continuous wave light sources of different wavelengths, mainly using the near-infrared light band of 600nm-900nm wavelength, and the wavelength of the light source is selected according to the excitation band of different fluorescent agents. Attenuator for adjusting the output power of the light source. In addition, it also includes an incident optical fiber from the light source system to the imaging cavity system and a collimator for collimating the incident light source.

[0038] Imaging chamber system for immobilizing and moving small animals. It includes a transparent imaging chamber for fixing small animals, a fiber holder for fixing the collimator and detection fiber, a motorized rotary table for rotating the imaging chamber, and an electric lifti...

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Abstract

The invention relates to the field of small animal imaging, solves the problems that in the prior art, the image resolution is low and the image acquisition time is long, provides a photon counting-type dynamic diffusion fluorescence tomography system which has high sensitivity and image resolution and achieves the purpose of dynamic diffusion fluorescence tomography with short measurement time. In order to achieve the purpose, the invention adopts the technical scheme as follows: the photon counting-type dynamic diffusion fluorescence tomography device comprises a light source system used for fluorescence excitation, an imaging chamber system used for fixing and moving a detected object, a light switch used for switching a detection passage, a light-filtering system used for filtering off excited light signals, a detection system used for detecting light signals, and a computer used for integrated control of an attenuator, the light switch, a motor-driven light filtering wheel, a photomultipler tube and a photon counting module as well as image reconstruction. The invention is mainly applied to small animal imaging.

Description

technical field [0001] The invention relates to the field of small animal imaging, in particular to a steady-state diffusion fluorescence tomography system for small animal tomography, in particular to a photon counting dynamic diffusion fluorescence tomography method and device. Background technique [0002] Diffuse optical tomography (Diffuse optical tomography, DOT) is a non-invasive detection technology based on tissue biochemical function information, which can detect centimeter-level thickness by using the information carried by diffuse light for highly scattering organs and tissues. In order to realize the detection of deeper tissues, near-infrared light with a wavelength of 600nm-900nm is often used as the light source, which is called the optical window (NIR window) for measurement and treatment [1]. Diffuse Fluorescence Tomography (DFT) is an extension and extension of optical tomography. It can not only reconstruct the distribution of tissue absorption and scatter...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01N21/64
Inventor 高峰王欣李娇马文娟赵会娟
Owner TIANJIN UNIV
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