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Pterocephalus hookeri (C.B.Clarke) Hoeck total saponin extract and preparation method and application thereof

A technology of total saponins and extracts, which is applied in the field of total saponins of pterygium and its preparation, to achieve good anti-inflammatory and analgesic effects and obvious anti-adjuvant arthritis effects

Inactive Publication Date: 2012-07-18
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] According to the existing literature, there are only reports that the total saponins and loganin in Pterocephalus have anti-inflammatory and analgesic effects, and the anti-tumor effects of total saponins, and the activity of total saponins in Pterocephalus in treating rheumatoid arthritis has not been seen yet. Ingredients Related Reports

Method used

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  • Pterocephalus hookeri (C.B.Clarke) Hoeck total saponin extract and preparation method and application thereof
  • Pterocephalus hookeri (C.B.Clarke) Hoeck total saponin extract and preparation method and application thereof
  • Pterocephalus hookeri (C.B.Clarke) Hoeck total saponin extract and preparation method and application thereof

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Embodiment 1

[0027] Embodiment 1 The preparation of the total saponins extract of Pterocephala of the present invention

[0028] Take 1000g of prairie herb and cut it into sections, add 1600ml of water to moisten it, decoct and extract it twice with 6000ml of water, 1.5h each time, filter, concentrate the filtrate, remove the precipitate by centrifugation, and dilute the water extract to 0.1g crude drug / ml of liquid medicine, adopt D101 type macroporous adsorption resin to load at room temperature, the flow rate of sample loading is 2BV / h, the sample volume is 1 times of the amount of resin (medicine: resin=1:1), eluted with 4BV water, flow rate 2BV / h, discard the eluent; elute with 3BV of 70% v / v ethanol, the elution flow rate is 3BV / h, the eluent is decompressed to recover ethanol, dissolve in 60% v / v ethanol, add Excessively saturated neutral lead acetate solution, stirred, so that the total saponins of pterygium completely precipitate, filter, take the precipitate and suspend in 70% v...

Embodiment 2

[0033] Embodiment 2 The preparation of the total saponins extract of pterygium of the present invention

[0034] Take 1000g of prairie herb and cut it into sections, add 1600ml of water to moisten it, decoct and extract it twice with 6000ml of water for 1.5h each time, filter, concentrate the filtrate, remove the precipitate by centrifugation, and dilute the water extract to 0.1g crude drug / ml of liquid medicine, adopt D101 type macroporous adsorption resin to load the sample at room temperature, the flow rate of the sample is 2BV / h, the sample volume is 1 times of the amount of the resin (medicine: resin = 1: 1), eluted with 4BV of water, the flow rate 2BV / h, discard the eluent; elute with 3BV of 70% v / v ethanol, the elution flow rate is 3BV / h, the eluent is decompressed to recover ethanol, dissolve in 80% v / v ethanol, add Excessively saturated neutral lead acetate solution, stirred to make the total pterocephalin completely precipitate, filter, take the precipitate and susp...

Embodiment 3

[0035] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0036]Take 100 g of total saponins prepared in Example 1, add appropriate starch, wet granulate, and dry to obtain the pharmaceutical composition granules of the present invention.

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Abstract

The invention provides a pterocephalus hookeri (C.B.Clarke) Hoeck total saponin extract, which is derived from a dry herb of a dipsacaceae plant, i.e., spathulate-leaf pterocephalus hookeri (C.B.Clarke)Hoeck. In the extract, the content of total saponins is more than 50 percent by weight, and the content of iridoid glycoside is 0-5 percent by weight. The invention further provides a preparation method and an application of the extract. The pterocephalus hookeri (C.B.Clarke) Hoeck total saponin extract provided by the invention is a total saponin part of pterocephalus hookeri (C.B.Clarke) Hoeck, has a remarkable effect on resisting adjuvant arthritis, good anti-inflammatory and analgesic effects, and can be used for effectively treating rheumatoid arthritis; and a novel option is provided for clinical administration.

Description

technical field [0001] The invention relates to a total saponin extract of pterygium and its preparation method and application, belonging to the field of medicine. Background technique [0002] Rheumatoid arthritis (RA) is a common systemic immune disease characterized by chronic polyarthritis, with hundreds of millions of patients worldwide. According to statistics, the prevalence rate of RA in foreign countries is 1-2%, and it is as high as 5% in some regions; the incidence rate in my country is about 0.74%, and there are about 10 million patients. According to the investigation, in the normal population, the incidence of rheumatoid arthritis accounts for about 0.35% of the normal population. The disability rate of this disease is high, and the disability rate of patients with rheumatoid arthritis who is not diagnosed and treated in time is 50% in two years and 70% in three years. The average life expectancy of patients with rheumatoid arthritis is shortened by 10 to 15...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/02A61P29/00
Inventor 张艺孟宪丽赖先荣古锐
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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