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Sodium valproate and preparation process thereof

A technology of sodium valproate and compound sodium valproate, applied in the field of medicine, can solve the problems of easy rebound, large toxic and side effects, slow onset of sodium valproate, etc., and achieves rational and orderly formulation and good therapeutic effect , deep and lasting effect

Active Publication Date: 2012-07-18
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of epilepsy, overcome the slow onset of western medicine sodium valproate, and easy to rebound, the problem of large toxic and side effects, to achieve the purpose of treating both symptoms and root causes

Method used

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  • Sodium valproate and preparation process thereof
  • Sodium valproate and preparation process thereof
  • Sodium valproate and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A compound sodium valproate pharmaceutical composition is characterized in that it is prepared from the following raw materials by weight ratio: 0.3 parts of sodium valproate, 30 parts of Danshen, 25 parts of pepper, 20 parts of Gansong, 12 parts of Gastrodia elata, Uncaria 10 parts.

[0039] Wherein the sodium valproate can be purchased commercially, and the preferred preparation method is:

[0040] 1. Feeding ratio

[0041]

[0042] 2. Production process

[0043] 2.1 Alkylation

[0044] Dry the reaction tank slightly, pump in n-bromopropane, add K2CO3 and TBAB, seal the mouth of the tank, start stirring and turn on the steam to reflux, add methyl acetoacetate dropwise, drop it in 10 minutes, reflux at normal pressure for 1 hour, and then pressurize Reflux for 2 hours (pressure 0.2-0.4Mpa), then add 200L of water at 70°C and heat up to dissolve, turn off the steam and stop stirring and let stand for 15 minutes to separate the water layer to obtain 200kg of crude ex...

Embodiment 2

[0058] clinical information

[0059] A total of 113 outpatients with complete medical records were selected. Among them, there were 52 males and 61 females; aged from 13 to 57 years, 48 ​​cases did not use medicine at all, 29 cases were treated with western medicine, 20 cases used occasionally, and 16 cases used intermittently; 37 cases had wind-phlegm obstruction syndrome, 35 cases of phlegm-heat internal closure syndrome, 19 cases of qi-blood stagnation syndrome, 18 cases of heart-spleen deficiency syndrome, and 4 cases of liver-kidney deficiency syndrome; the patients were randomly divided into two groups according to specific conditions such as gender, age, condition, and medication. 2 groups, 60 cases in the treatment group and 53 cases in the control group.

[0060] Epilepsy Diagnostic Criteria

[0061] TCM syndrome diagnostic criteria: (1) wind-phlegm blockage syndrome: before the attack, there are auras such as chest tightness and dizziness; There are dizziness, tir...

Embodiment 3

[0071] typical embodiment

[0072] Chen, female, 26 years old, suffered from epileptic seizures due to high fever three years ago, convulsions in limbs, sudden coma, stiff neck and back, foaming at the mouth, closed teeth, upward vision, and occasional urinary incontinence and other symptoms. The attack lasts for 3-5 minutes. After the attack is relieved by itself, there are often symptoms such as headache, fatigue, nausea, and vomiting. After a few hours, it returns to normal. Since the onset of the disease, the patient has been diagnosed and treated in major hospitals in the local area and Beijing many times, but his condition has not improved significantly, and the EEG examination is severely abnormal, with epileptiform discharges. According to the patient's introduction, after taking the compound sodium valproate prepared in Example 1 for 2 courses of treatment, the symptoms were controlled, and the consolidation treatment was continued. After half a year of reexamination,...

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PUM

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Abstract

The invention relates to compound sodium valproate and a preparation process thereof. The sodium valproate is prepared by raw materials including sodium valproate 0.3 part, salvia miltiorrhiza 30 parts, pepper 25 parts, rhizoma nardostachyos 20 parts, gastrodia elata 12 parts and uncaria 10 parts by weight, and the sodium valproate is prepared into capsules, tablets, particles and other drug forms after pharmaceutical excipients such as starch or edible cellulose are added according to a common pharmacy method. A compound sodium valproate drug composition treats both principal and secondary aspect of epilepsia disease, is non-toxic harmless and free of side effect to human body, low in price, simple and convenient to manufacture, and has wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to Chinese and western medicine preparations for treating epilepsy, in particular to the application of medicines made of western medicine sodium valproate and Chinese herbal medicine in epilepsy. Background technique [0002] Epilepsy (Epilepsy, EP) is a recurrent, short-term brain dysfunction syndrome caused by temporary excessive high-frequency discharge of brain neurons. It is manifested as sudden onset, automatic termination, and recurrent disturbances in movement, sensation, spirit, and consciousness. It is a chronic convulsive disease. According to incomplete statistics, the current incidence of epilepsy in my country is about 6‰, with nearly 9 million patients, and there are about 450,000 new patients every year. Most studies have found that the incidence of epilepsy in men is 57.1%, which is higher than that in women (42.7%), and the incidence in rural areas is higher tha...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/08A61K31/19
Inventor 赵振桥聂昌盛张玉美徐平田王丽娟杜宾芳
Owner 仁和堂药业有限公司
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