Veterinary compound tulathromycin nanoemulsion and preparation method thereof

Abstract

The invention discloses veterinary compound tulathromycin nanoemulsion injection. Particle size of the nanoemulsion ranges from 1nm to 100nm and is made of the following raw materials in percentage by weight: 30%-40% of surfactant, 5%-15% of cosurfactant, 5%-15% of oil, 2%-5% of tulathromycin, 0.5%-1.25% of trimethoprim lactate, and the balance of deionized water. Bacteriostasis is achieved by administration of the injection once, and the bacteriostasis is quick and is slowly released. The nanoemulsion is capable of avoiding first pass effect of hepar and has neural pH so that animal stress reaction is reduced. The veterinary compound tulathromycin nanoemulsion injection is high in safety, simple to prepare and low in energy consumption, can be produced massively without special equipment, and has broad market prospect in the field of medicine.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of telamycin with antibacterial effect, in particular to a transparent and stable oil-in-water compound telamycin nanoemulsion injection and a preparation method thereof. Background technique Tulathromycin (Tulathromycin) is a newly marketed macrolide semi-synthetic antibiotic exclusively for animals. The Ministry of Agriculture of my country firstly allowed the use of telamycin in animal production in Announcement No. 957 in 2008. Tyramycin is a broad-spectrum antibacterial drug, which is effective against pathogenic bacteria that cause respiratory diseases in pigs and cattle, such as Pasteurella hemolyticus, Pasteurella multocida, Haemophilus somnus, Mycoplasma, Actinobacillus pleuropneumoniae, bronchial septicemia Bordetella, Haemophilus parasuis, etc., and Moraxella bovis, which causes bovine infectious keratoconjunctivitis, are particularly sensitive. It has many ...

AI Technical Summary

Problems solved by technology

Tyramycin currently used for injection is a suspension, which is inconvenient to use, easy to block pinholes, low bioavailability, and poor absorption

There is also a method of dissolving telamycin in dilute acid for injection, which also faces two problems: 1) dilute ac

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