Metoprolol tartrate/seabuckthorn oil nanoemulsion antihypertensive drug

Abstract

The invention discloses an oil-in-water type metoprolol tartrate / seabuckthorn oil nanoemulsion antihypertensive drug which is characterized in that the nanoemulsion antihypertensive drug has particle size of 30.1-71.8 nm. The drug comprises the following raw materials by weight: 1-20% of metoprolol tartrate, 15-40% of surfactant, 1-25% of co-surfactant, 1-25% of seabuckthorn oil, and the balance of distilled water. The sum of the mass percent of the raw materials is 100%. The nanoemulsion preparation organically combines water-soluble drug metoprolol tartrate and lipid-soluble seabuckthorn oil, to improve dissolution and penetration abilities of seabuckthorn oil, and improve stability and medicinal effect of metoprolol tartrate. The metoprolol tartrate / seabuckthorn oil nanoemulsion combines advantages of metoprolol tartrate and seabuckthorn oil to obviously improve antihypertensive effect, prolong half life of drug, and reduce administration times.

Description

Technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of antihypertensive drug metoprolol tartrate and sea buckthorn oil, in particular to a nanoemulsion antihypertensive medicine metoprolol tartrate and sea buckthorn oil. Background technique [0002] Metoprolol Tartaric Acid, full name: 1-isopropylamino-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L(+)-tartrate, molecular formula : (C 15 H 25 NO 3 )2·C 4 H 6 O 6 , Molecular weight: 684.8. This product is a β-receptor blocker with weak membrane stabilization and no endogenous sympathomimetic activity. It has a large selective effect on the β-receptors of the heart. Β on vascular and bronchial smooth muscle at larger doses 2 The receptor also has a role. It can slow down the atrioventricular conduction and slow down the sinus heart rate. It can also slow down the heart rate, reduce cardiac output, and reduce systolic blood pressure. This drug belongs to category 2A, that is, β w...

AI Technical Summary

Problems solved by technology

There are antihypertensive drugs such as metoprolol tartrate tablets on the market, and the use of seabuckthorn oil is also available. Although it can be absorbed from the gastrointestinal tract after oral administration, the absorption is not complete. In addition, the dissolution rate of the drug is slow and the bioavailability is poor. Coupled with the slow action of metoprolol tartrate, the efficacy of metoprolol tartrate and seabuckthorn oil cannot be utilized