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Novel rheumatoid arthritis disease marking system and application

A rheumatoid and arthritis technology, applied in the field of rheumatoid arthritis disease scoring system, can solve the palm and finger joints affecting the four paws, evaluate the occurrence, course, nursing, treatment, and Other intervention barriers, the incidence of facet joints and the severity of the disease are not included in the score, so as to achieve the effect of sensitive evaluation

Inactive Publication Date: 2012-10-24
上海浦灵生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are many defects in the existing rheumatoid arthritis disease scoring system, for example: animals often have limited mobility and decreased appetite in the early or acute stage of onset, which is not particularly closely related to the severity of arthritis; Similar to patients, arthritis in monkeys mainly affected the metacarpal and phalangeal joints of the four paws, with few significant lesions observed in large joints; incidence and disease severity of small joints were not included in the score
Since the existing scoring system for rheumatoid arthritis cannot truly and completely reflect the severity of the disease and cover all stages of the disease, it will play an important role in evaluating the occurrence, course, nursing, Barriers to treatment, and other interventions

Method used

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  • Novel rheumatoid arthritis disease marking system and application
  • Novel rheumatoid arthritis disease marking system and application
  • Novel rheumatoid arthritis disease marking system and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Using the existing scoring system, the limbs of each animal were scored separately: 0 = normal; 1 = mild arthritis, lesions limited to the paw facet joints (finger and toe joints); 2 = moderate arthritis, lesions involved Small and large joints (elbow, knee); 3 = severe arthritis, lesions involving large and small joints, limited movement; 4 = limited movement, difficulty eating, trunk or distal limb paralysis. The disease score of each animal is the sum of the scores of the four limbs, and the average value of each group of animals is drawn in a graph (see appendix figure 1 ).

[0040] Using the scoring system of the present invention, the above-mentioned 64 joints of each animal are scored, and the disease score of each animal is equal to the sum of the scores of all the above-mentioned joints, and the average value of each group of animals is used to draw a curve (see the appendix figure 2 ).

[0041]Two-way RM ANOVA with Bonferroni post-tests data statistics meth...

Embodiment 2

[0059] The inventor also adopted another data statistics method, One-way RM ANOVA with Newman-Keuls post-tests, to further compare the scoring results of the scoring system of the present invention with the existing scoring system.

[0060] 1) Comparison of scoring results of existing scoring systems

[0061] mean difference q value Significance (P result Control group and model group -4.563 7.181 yes *** Control group and treatment group -2.125 3.344 yes * Administration group and model group -2.438 3.836 yes *

[0062] *P<0.05, ***P<0.001

[0063] 2) Comparison of scoring system scoring results of the present invention

[0064] mean difference q value Significance (P result Control group and model group -32.81 5.546 Yes ** Control group and treatment group -6.875 1.162 no ns Administration group and model group -25.94 4.384 Yes **

...

Embodiment 3

[0069] The recorded data generated by the scoring system of the present invention can also be analyzed separately for the proximal finger joint PIP disease score. Since the main lesion of rheumatoid arthritis involves the little finger joint such as the proximal finger joint PIP, the disease of this joint is simply analyzed. Score analysis, while greatly reducing the workload, can still accurately monitor the development of rheumatoid joint disease and provide an accurate and reliable scientific basis for the efficacy evaluation of the drug to be tested. However, the existing scoring system is due to the amount of information However, the limitations of this method are that it is not possible to derive disease score data for specific joints such as PIP.

[0070] The 20 PIP joints of each animal are scored, and the disease score of each animal is equal to the sum of the scores of all the above-mentioned PIP joints, and the average value of each group of animals is used to draw a...

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Abstract

The invention discloses a novel rheumatoid arthritis disease marking system. The marking system participates in marking on 64 joints including all phalangeal joints, wrist / ankle joints and elbow / knee joints, the marking of each joint comprise normal, light, medium and serious levels, the recording information is complete, the total score of each test animal can be calculated, and the special joints can be respectively counted and marked. Compared with the existing marking system, the disease marking system disclosed by the invention has the advantages that the monitoring on the development process of the rheumatoid arthritis diseases and the evaluation on the medicine curative effect reaction are sensitive, and a wider medicine treatment window can be provided. In addition, because the recorded information content is complete, data recorded by the marking system can derive out multi-term other evaluation indexes, and extensive, more detailed and more complete basis is provided for accurately monitoring the development process of the rheumatoid arthritis diseases and testing the evaluation the medicine curative effect evaluation.

Description

technical field [0001] The invention relates to the field of disease scoring, and relates to a scoring parameter analysis method for disease-related factors, in particular to a scoring system for rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a chronic systemic autoimmune disease with unknown etiology and characterized by joint synovitis, which occurs in small joints such as hands, wrists, and feet. Destruction of cartilage and bone, joint dysfunction, and even disability. The main goal of current clinical treatment is to control joint inflammation and pain, maintain joint function as much as possible, prevent, reduce or slow down joint bone damage and deformation. So far, there is no method that can completely cure rheumatoid arthritis. [0003] The Disease activity score (DAS) scoring system is an international clinical clinical rheumatoid arthritis disease scoring system, which is used to describe the severity of the disease, and is also used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
Inventor 刘俊娥邓继林宋之战张红倪佳傅恩赐
Owner 上海浦灵生物科技有限公司