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A medicine for treating cervical erosion
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A technology of cervical erosion and drugs, which is applied in the field of drugs for the treatment of cervical erosion, can solve problems such as not showing significant therapeutic advantages, causing pelvic inflammatory diseases, and drug residues breeding bacteria, etc., to achieve stable process, controllable quality, effective ingredients The effect of high content
Inactive Publication Date: 2016-05-11
BEIJING TIANKE RENXIANG MEDICAL SCI TECH
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[0004] At present, there are many kinds of drugs clinically used to treat gynecological inflammatory diseases. Among them, the traditional Chinese patent medicines in my country account for 71% of the market share, while chemical drug preparations only account for 29%. However, there are not enough products clinically used to treat cervical erosion 20, some traditional Chinese medicine preparations such as dispersible, ointment, and suppository have not been used clinically
[0006] (2) Aibao therapy: an imported product for the treatment of vaginal and cervical inflammation. There are two preparations, concentrate and suppository. Its main component is polycresol, which is used as a chemical drug. Significant therapeutic advantages, research results show that the cure rate of mild cervical erosion is 87.3%, and the cure rate of 1 course of treatment is low, need to adhere to 2 to 3 courses of treatment, at the same time, Aibo therapy is easy to cause the breeding of drug residues Bacteria, causing pelvic inflammatory disease and other diseases, the lack of the product itself will have a serious impact on product competitiveness
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experiment example 1
[0061][Experimental Example 1]: Study on the Extraction Process of Medicinal Materials
[0062] 1.1 Investigation of extraction solvent:
[0063] Chromatographic conditions: octadecylsilane bonded silica gel as filler; acetonitrile-water (55:45) as mobile phase; detection wavelength is 310nm; column temperature is 25°C; flow rate is 1ml / min.
[0064] Preparation of the reference solution: take an appropriate amount of osthole, accurately weigh it, add ethanol to make a solution containing 100 μg per 1 ml, and obtain it.
[0065] The preparation of need testing solution: get about 100g of Fructus Cnidii powder (crossing the No. 3 sieve), three parts, accurately weighed, put in the round bottom flask, add ethanol, water, ethyl acetate 10 times amount respectively, reflux extraction three times, Each time for 1 hour, the filtrates were combined, the solvent was recovered under reduced pressure, and dried at low temperature. Take an appropriate amount of dry paste, dissolve it i...
experiment example 2
[0102] [Experimental Example 2]: Purification process investigation of total coumarin
[0103] 2.1 Investigation of water precipitation method:
[0104] It can be seen from the references that the coumarin components of osthole are mostly in the lipophilic free form, soluble in general organic solvents, and the solubility in water is very small, so it is considered to remove part of the hydrophilicity in the extract by water precipitation. Impurities.
[0105] 2.1.1 Investigation of water consumption:
[0106] Accurately weigh 10g of the above-mentioned extract, six parts, place in a conical flask, add purified water of the corresponding extract amount (v / g) respectively, stir evenly, let stand for 4 hours, filter, collect the filtrate, evaporate the solvent, Impurities are dissolved in ethanol, and HPLC is used to determine whether osthole is contained in the impurities. Another precipitate was collected, dried at low temperature, weighed, and an appropriate amount was dis...
experiment example 3
[0146] [Experimental Example 3]: Study on preparation molding process
[0147] 3.1 Choice of dosage form
[0148] This product is a vaginal effervescence made from the effective part-total coumarin extract extracted from the dried and mature fruit of the Umbelliferae plant Cnidium through a certain process, and the excipients screened by the orthogonal test, and the preparation molding process is optimized. Tablets, improve their bioavailability, thereby improving clinical efficacy.
[0149] Due to the large amount of foam produced by the disintegration of effervescent tablets, the direct contact between the drug and the lesion is increased, and its curative effect can be better exerted. Therefore, effervescent tablets are suitable for the prevention and treatment of vaginal diseases, and they have rapid disintegration and effective Rapid, high bioavailability, easy to store and carry.
[0150] 3.2 Screening of excipients and dosage investigation
[0151] 3.2.1 Selection of...
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Abstract
The invention discloses a medicine for treating cervical erosion, which belongs to the technical field of an innovative medicine preparation in traditional Chinese medicines. According to the product, a traditional Chinese medicinal material fructus cnidii in China is taken as a raw material, effective part total coumarins are obtained by extraction through the processes of alcohol extraction, concentration, acid / alkali purification and the like, and a vaginal effervescent tablet is prepared by processing through adopting a modern preparation technology. Because the direct contact of the medicine and a part with pathological change is increased by a great number of foam generated by the disintegration of the medicine for treating the cervical erosion, the curative action of the medicine for treating the cervical erosion is better exerted. The medicine for treating the cervical erosion is suitable for serving as a medicine for preventing and treating vaginal diseases. Moreover, the medicine for treating the cervical erosion is quick to disintegrate, is rapid to act and has high bioavailability. Moreover, the medicine for treating the cervical erosion is convenient to preserve and carry. The medicine disclosed by the invention has the effects of eliminating dampness, diminishing inflammation, removing putrefaction and promoting tissue regeneration and is mainly used for patients with syndromes, such as leukorrheal diseases caused by the damp invasion of lower energizers with the symptoms of much leukorrheal quantity and yellowness or whiteness in color, or purulency and sagging distention in the waist and the abdomen, or dribbling, difficulty and pain in urination, or pruritus vulvae, bitterness in the mouth, dryness in the throat, redness in the tongue, yellowness or greasiness in the fur, slipperiness or tautness in the pulse and the cervical erosion.
Description
technical field [0001] The invention belongs to the technical field of innovative traditional Chinese medicine preparations, and relates to a medicine for treating cervical erosion. Background technique [0002] Cervical erosion is a chronic inflammation, the most common type of chronic cervicitis. Due to inflammation stimulation, the epithelial cells on the surface of the cervix fall off, and the columnar epithelial cells below protrude outward to replace the exfoliated epithelium. The exposed capillaries of the columnar epithelium make the inflammatory area bright red, so it is called cervical erosion. . Cervical erosion is a common disease in women, frequently-occurring, mostly in married women. [0003] Epidemiological survey results show that the incidence of cervical erosion in rural women is higher. With the changes in people's living environment and habits, the incidence of cervical erosion in women is on the rise. Statistics show that cervical erosion is a commo...
Claims
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Application Information
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