Paeonol inclusion compound and preparation method thereof

A technology of paeonol and clathrate, applied in the field of paeonol clathrate and its preparation, can solve the problems of poor taste-masking effect, low clathrate rate, poor water solubility, etc., and achieve good taste-masking effect, Good stability and increased water solubility
CN102784131BActive Publication Date: 2014-04-16HUBEI TIANSHENG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUBEI TIANSHENG PHARMA
Publication Date
2014-04-16

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Abstract

The invention provides a paeonol inclusion compound. A compound agent is a mixture of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin; the molar ratio of the beta-cyclodextrin to the hydroxypropyl beta-cyclodextrin is (10:1)-(1:1); and the molar ratio of paeonol to the compound agent is (1:12)-(1:10). The paeonol inclusion compound has greatly increased water-solubility, good stability, difficulty in separation, and an excellent taste masking effect; and the compound rate can reach to more than 80 percent.
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Description

Technical field:

[0001] The invention belongs to the field of medicine, and relates to an inclusion compound of paeonol and a preparation method thereof. technical background:

[0002] Paeonol is the main active ingredient in the bark of Paeonia moutan Sim. and the whole plant of Pycnostelma paniculatum K. Schum. Its chemical formula is 2-hydroxy-4-methoxybenzene Ethyl ketone, the molecular formula is C 9 h 10 o 3 , the relative molecular mass is 166.18. Paeonol is white or light yellow crystal or crystalline powder, with specific odor, slightly spicy taste, easily soluble in ethanol and methanol, soluble in hot water, insoluble in cold water, can volatilize with water vapor, melting point 48 ℃ ~ 51 ℃. Paeonol has a wide range of pharmacological activities, and has analgesic, anti-inflammatory, antipyretic and anti-allergic effects, sedative, hypnotic, antibacterial, anti-inflammatory, anti-oxidant, and blood pressure-lowering effects. Immune system and other diseases;...

Claims

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