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Tongzhisurunjiang tablet for activating retardation and softening and preparation and quality control method thereof

A technology for stagnation of Surunjiang and Surunjiang tablets, applied in the field of pharmaceutical preparations, can solve the problems of increasing the difficulty of tableting and forming, affecting the quality stability of preparations, and exuding, and achieves reliable quality control methods, small side effects, and good friability. Effect

Active Publication Date: 2014-02-26
WUHAN JIANMIN ZHONGWEI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These oily ingredients further increase the difficulty of tablet molding, and will ooze out from the tablet after a long period of storage, thus affecting the quality stability of the preparation

Method used

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  • Tongzhisurunjiang tablet for activating retardation and softening and preparation and quality control method thereof
  • Tongzhisurunjiang tablet for activating retardation and softening and preparation and quality control method thereof
  • Tongzhisurunjiang tablet for activating retardation and softening and preparation and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Tongzhi Surunjiang tablet comprises a tablet core, and the tablet core is made of the following raw materials in parts by weight:

[0051] Senna leaf 70.8g, colchicum 100g, myrobalan meat 30g, box fruit 100g, almond 95.8g, saffron 5g, scamonia fat 12.5g;

[0052] Microcrystalline cellulose 50g;

[0053] Micropowder silica gel 30g;

[0054] Light magnesium carbonate 15g;

[0055] Hydroxypropyl methylcellulose 0.5g

[0056] Magnesium stearate 2.5g.

[0057] The preparation method of described tablet core is:

[0058] (1) Get senna leaves, colchicum, myrobalan meat, box fruit, almonds, saffron, scamonia fat, and grind them into fine powder;

[0059] (2) Add microcrystalline cellulose, micropowder silica gel, light magnesium carbonate to the above-mentioned fine powder, and mix uniformly;

[0060] (3) Take hydroxypropyl methylcellulose to make a solution with a mass concentration of 0.5%, add it to the above-mentioned uniformly mixed powder, and make granules;

[0061]...

Embodiment 2

[0066] Tongzhi Surunjiang tablet comprises a tablet core, and the tablet core is made of the following raw materials in parts by weight:

[0067] Senna leaf 70.8g, colchicum 100g, myrobalan meat 30g, box fruit 100g, almond 95.8g, saffron 5g, scamonia fat 12.5g;

[0068] Microcrystalline cellulose 60g;

[0069] Micropowder silica gel 20g;

[0070] Light magnesium carbonate 10g;

[0071] Povidone 1g

[0072] Magnesium stearate 5g.

[0073] The preparation method of described tablet core is with embodiment 1.

[0074] The content of gallic acid in each tablet of this product is 0.51mg.

[0075] The mass percentage of ether-soluble extract in each tablet of this product is 6.5%.

Embodiment 3

[0077] Tongzhi Surunjiang tablet comprises a tablet core, and the tablet core is made of the following raw materials in parts by weight:

[0078] Senna leaf 70.8g, colchicum 100g, myrobalan meat 30g, box fruit 100g, almond 95.8g, saffron 5g, scamonia fat 12.5g;

[0079] Microcrystalline cellulose 30g;

[0080] Micropowder silica gel 40g;

[0081] Light magnesium carbonate 20g;

[0082] Carbomer 0.1g

[0083] Magnesium stearate 1g.

[0084] The preparation method of described tablet core is with embodiment 1.

[0085] The content of gallic acid in each tablet of this product is 0.49mg.

[0086] The mass percent content of ether-soluble extract in each tablet of this product is 7.1%.

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Abstract

The invention discloses a tablet for activating the retardation and softening, which can smoothen retardation and relieve swelling and pain, and can treat articular bone pain, rheumatism, rheumatoid arthritis and sciatica. According to the tablet, a core of the tablet comprises seven traditional Chinese medicines which are respectively folium sennae, colchicum autumnale and medicine terminalia fruit and the like, and microcrystalline cellulose, aerosil, light magnesium carbonate, an adhesive and magnesium stearate. The invention also discloses a preparation method for the tablet, and a quality control method for the Tongzhisurunjiang tablet. The tablet activating the retardation and softening disclosed by the invention has the characteristics of high tabletting strength, high friability and is easy to form, and has characteristics of resistance to oil leakage, and high stability; compared with troche, the tablet is more convenient to take and carry, is low in cost, and less in side effect. The preparation technology disclosed by the invention is simple, and the quality control method is reliable; and the quality of a product can be controlled well.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to Tongzhi Surunjiang Tablet, and also relates to a preparation and quality control method of Tongzhi Surunjiang Tablet. Background technique [0002] "Ministry of Health of the People's Republic of China Drug Standards Uighur Drug Sub-Book" (Pharmacopoeia Committee of the Ministry of Health of the People's Republic of China, 1998) records a kind of opening block, swelling and pain relief, used for joint bone pain, rheumatism, rheumatoid arthritis and The traditional Chinese medicine for sciatica is called Tongzhi Surunjiang Capsule, and the standard number is WS3-BW-0182-98. The medicine is made by crushing 42.5g of senna leaves, 60g of colchicum, 18g of myrobalan meat, 60g of box fruit, 57.5g of almonds, 3g of saffron, and 7.5g of scamonia fat into fine powder, and then combined with single Syrup and starch are granulated and then filled with capsules. [0...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K9/20A61P29/00A61P19/02A61P19/08G01N30/02G01N30/06
Inventor 熊富良张琼光向阳李崇明朱立彬
Owner WUHAN JIANMIN ZHONGWEI PHARMA CO LTD
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