A kind of overall release Buyang Huanwu controlled sustained-release preparation and preparation method thereof

Abstract

The invention provides a preparation method for integrally controlling multiple components of the Yang recuperating controlled and sustained release preparation to release. Various types of controlled and sustained release preparations can be prepared by the controlled and sustained release preparation by utilizing osmotic pressure and membrane controlled release principles. The preparation method comprises the following steps of: adding starch, dextrin, water-soluble high-molecular polymer, hypertonic substances and other auxiliaries into the extract of the Yang recuperating prescription to prepare a tablet core; and coating the tablet core with the water-soluble polymer liquid containing a pore-forming agent, and poring to prepare an osmotic pump tablet; and preparing a microporous film coating tablet by adopting the high-molecular material and the pore-forming agent; and preparing controlled and sustained micropills, microspheres and small tablets by adopting the film controlled and sustained release material, or filling into hard capsule shells to prepare hard capsules. The invention also provides an integrally releasing Yang recuperating controlled and sustained release preparation, which can release multiple components of the drug in an integral and controlled way, so that the acting time of the medicament can be prolonged, the number of administration times can be reduced, and the compliance of clinical patient administration can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a controlled-sustained-release preparation of a compound traditional Chinese medicine, in particular to a multi-component medicine integral controlled-sustained-release preparation of a classic famous prescription Buyang Huanwu Decoction and a preparation method thereof. Background technique [0002] Buyang Huanwu Decoction was first recorded in "Yilin Gaicuo" by Wang Qingren in the Qing Dynasty. The whole prescription is composed of 60g astragalus, 9g angelica, 6g Chuanxiong, 9g red peony, 9g peach kernel, 9g safflower, and 9g earthworm. The function of collateral dredging, later research further showed that it has preventive and therapeutic effects in antithrombotic, antiaging, anticerebrovascular, antiblood lipid and regulating immune function, especially in acute ischemic stroke (cerebral infarction). It can play a good preventive and therapeutic role in the attack period, the...

AI Technical Summary

Problems solved by technology

[0010] When using the overall skeleton drug delivery, if the drug and the matrix can be eroded (dissolved) from the outside to the inside at the same time, the drug can also reflect the synchronous and overall controlled release of the multi-components of the traditional Chinese medicine compound, but the matrix mostly needs water-soluble polymer materials. It is inconvenient to achieve the goal of sustained and controlled release; if the overall non-erodible matrix drug delivery system is used, the components will diffuse and dissolve from the matrix material. Because the diffusion coefficients of each component are different, it is difficult to be the same as the composition ratio required by the original decoction. Therefore, the drug Poor overall controllability

Therefore, this technology is not an ideal Chinese medicine compound multi-component controlled sustained-release drug delivery system;

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