Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of ginkgolic acids in preparation of external preparation for treating cutaneous tumors

A technology of ginkgolic acid and external preparations, applied in the field of biomedicine, which can solve the problems of unseen uses of ginkgolic acid, obvious toxic and side effects of radiotherapy and chemotherapy, and patients' intolerance, so as to achieve no skin irritation, inhibit tumor growth, and inhibit proliferation Effect

Inactive Publication Date: 2013-01-02
王青
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some patients cannot accept surgical treatment, and surgical treatment, radiotherapy, and chemotherapy are harmful to patients, and the side effects of radiotherapy and chemotherapy are obvious, and some patients cannot tolerate it.
There is no report on the use of ginkgolic acid in the preparation of external preparations for the treatment of skin tumors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of ginkgolic acids in preparation of external preparation for treating cutaneous tumors
  • Use of ginkgolic acids in preparation of external preparation for treating cutaneous tumors
  • Use of ginkgolic acids in preparation of external preparation for treating cutaneous tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).

...

Embodiment 2

[0025] The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0026] G...

Embodiment 3

[0030] The extraction process of ginkgophenolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0031] Ginkgo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a use of ginkgolic acids in preparation of an external preparation for treating cutaneous tumors. The ginkgolic acids comprise ginkgolic acid, bilobol and ginkgol and can be extracted from leaves, fruits, testa and rootstocks of gingko by a chemical separation method. A ginkgolic acid-containing external preparation for treating cutaneous tumors comprises 0.001 to 80wt% of ginkgolic acids and a pharmaceutically used common external preparation matrix or pharmaceutically acceptable carriers. The ginkgolic acid-containing external preparation for treating cutaneous tumors is an external dosage form defined by all pharmaceutics. A pharmacological experiment research shows that ginkgolic acids have effects of inhibiting cutaneous tumor generation, cutaneous cancer cell propagation and tumor growth and improving a survival rate, are safe and have no side-effect and a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the use of ginkgolic acid in the preparation of external preparations for treating skin tumors. Background technique [0002] Skin cancer is one of the common malignant tumors in humans. In the past two decades, the incidence of human skin tumors has increased significantly, and continues to grow at a rate of 4% per year. Skin squamous cell carcinoma can occur in normal skin, and can also develop from precancerous lesions such as solar keratosis. It has strong invasiveness and metastasis, and is clinically harmful. Therefore, people have been exploring effective treatment options for skin tumors. Skin tumors can adopt comprehensive treatment methods such as surgical treatment, radiotherapy, chemotherapy, and traditional Chinese medicine treatment. However, some patients cannot accept surgical treatment, and surgical treatment, radiotherapy, and chemotherapy are harmful to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/16A61K31/60A61K31/05A61P35/00
Inventor 雷红王青
Owner 王青
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com