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Nanometer composite scaffolds assembled by adopting chitosan scaffold, preparation method and applications thereof

A nano-composite and chitosan technology, applied in the field of nano-materials, can solve the problems of difficult to prepare three-dimensional nano-assembled structures, and achieve the effects of wide applicability, excellent performance and simple operation.

Inactive Publication Date: 2014-04-02
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] From page 1039 of the tenth volume of the Chinese "Nano Dimensions" journal, it is reported that polymer electrospinning is used to assemble nanomaterials to form one-dimensional fibers, which are then stacked to form electrospun films. Similarly, it is difficult to prepare three-dimensional nanomaterials by secondary assembly methods. Assembly structure

Method used

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  • Nanometer composite scaffolds assembled by adopting chitosan scaffold, preparation method and applications thereof
  • Nanometer composite scaffolds assembled by adopting chitosan scaffold, preparation method and applications thereof
  • Nanometer composite scaffolds assembled by adopting chitosan scaffold, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Dissolve 1.0 g of chitosan powder in 50 mL of 2% aqueous acetic acid to prepare a chitosan solution with a concentration of 20 mg / mL. The frozen metal sheet was pre-frozen to -40°C with liquid nitrogen, and the silicone mold was placed on the stainless steel metal sheet, and then the chitosan solution was poured into the mold, and after freezing and forming, as for the freeze dryer (Labconco-195,-45 ℃) freeze-dried. The lyophilized chitosan scaffold was soaked in NaOH solution with a concentration of 1.0mol / L to neutralize excess acetic acid, and the excess NaOH solution was washed away with distilled water.

[0060] Fe 3 o 4 Preparation of nanoparticles: first prepare solution 1: weigh 2 grams of sodium hydroxide and add it to 20 milliliters of diethylene glycol, vacuumize, vent nitrogen, add a reflux tube, heat to 120 ° C for one hour, and then keep the temperature at 70 ° C. Prepare solution 2: Weigh 0.064 g of anhydrous ferric chloride, 0.288 g of PAA (Mw: 1800),...

Embodiment 2

[0064] The chitosan scaffold was prepared as in Example 1.

[0065] Preparation of Au nanoparticles: Measure 96mL of deionized water into a round bottom flask, add 2mL of 50mM chloroauric acid solution, transfer to 120°C oil bath and boil for half an hour, weigh 0.1144g of trisodium citrate and dissolve in 2.5ml of water , and added to the above reaction system, continued to boil for 10 minutes, took out the flask to stop the reaction. The whole process adds the reflux of the condenser tube. (G. Frens, Controlled Nucleation for Regulation of Particle-Size in Monodisperse Gold Suspensions. Nature-Physical Science 241, 20 (1973).)

[0066] Immerse the chitosan foam with acetic acid removed into the 5ml aqueous solution of Au nanoparticles prepared above at a concentration of 1mg / mL, repeatedly squeeze and release the foam until the solution is almost clear, so that the Au nanoparticles are adsorbed to the inner wall of the foam channel, and the assembled The composite scaffold...

Embodiment 3

[0069] The chitosan scaffold was prepared as in Example 1.

[0070] Preparation of Ag nanoparticles: measure 96mL of deionized water to a round bottom flask, add 1mL of 50mM silver nitrate solution, transfer to 120°C oil bath and boil for half an hour, weigh 0.1144 grams of trisodium citrate and dissolve in 2.5 milliliters of water, And add in the above reaction system, continue to boil for 5 minutes, take out the flask to stop the reaction. The whole process adds the reflux of the condenser tube. (G. Frens, Controlled Nucleation for Regulation of Particle-Size in Monodisperse Gold Suspensions. Nature-Physical Science 241, 20 (1973).)

[0071] Immerse the chitosan foam with acetic acid removed into the 5ml Ag nanoparticle aqueous solution prepared above at a concentration of 1mg / mL, repeatedly squeeze and release the foam until the solution is almost clear, so that the nanoparticles are adsorbed to the inner wall of the foam channel to obtain an assembly Composite support ma...

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Abstract

The present invention provides a method for achieving assembly of a macroscopic size nanometer material and obtaining a series of functional nanometer composite scaffolds by adopting a chitosan scaffold as a matrix, wherein the series of the functional nanometer composite scaffolds are obtained by assembling various functional nanometer materials in a chitosan scaffold. The method specifically comprises that: unidirectional freezing is performed to obtain a chitosan porous scaffold, the chitosan porous scaffold is immersed into a nanometer material aqueous solution, and the nanoparticles are adsorbed onto the surfaces of pore channels inside the chitosan porous scaffold so as to obtain the nanometer composite scaffold; or a nanometer material is directly mixed in a chitosan solution before a chitosan porous scaffold is obtained, and then unidirectional freezing is performed to obtain the nanometer composite chitosan porous scaffold. The method of the present invention has characteristics of simple operation and wide applicability, and can be applicable for mass preparation of required products. According to the nanometer composite scaffold of the present invention, the reversible shape resilience performance of the original chitosan porous scaffold is provided, and the functionality of the nanometer material is provided for the final macroscopic scaffold, such that important guiding effects are provided for applications of various functional nanometer materials in optics, electricity, magnetism, thermotics, biomedicine, and other fields.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and specifically relates to a preparation method for assembling a variety of functional nanomaterials in a three-dimensional macroscopic size and realizing their functions on a macroscopic support after assembly; it also relates to a nanocomposite prepared by the method Scaffolds and their applications. Background technique [0002] At present, the research on the assembly technology of nanomaterials is very active, and researchers are trying a series of methods to assemble nanomaterials to form new functional materials. Among them, using polymers as templates to induce the assembly of nanomaterials is considered to be a very effective way. The assemblies formed by this method include discrete polymers, one-dimensional chains, two-dimensional films or arrays, and three-dimensional superlattice structures. [0003] However, most of these assemblies still stay at the nanoscale, or the assem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/40C08J9/28C08L5/08A61L27/20A61L31/04
Inventor 俞书宏高怀岭茅瓅波
Owner UNIV OF SCI & TECH OF CHINA
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