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Antibiosis fishing medicament processing method

A processing method and antibacterial drug technology, which is applied in the field of antibacterial fish drug processing, can solve the problems of low drug administration efficiency, slow release, drug loss, etc., and achieve the effects of not easy to disperse, uniform pore distribution, and improved stability

Inactive Publication Date: 2015-04-29
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current drug delivery method is generally to put it directly or mix it into the feed, but because the antibacterial drug is easily dissolved in the water after contacting the waters, first of all, its drug delivery efficiency is too low to ensure that fish, shrimp and other aquatic animals eat it, and it cannot Estimate the amount of food and medicine for each aquatic animal, so its efficacy cannot be guaranteed, and it is very blind; secondly, it is also easy to pollute the water quality of the water area. Since the water area is mobile and public, it will also affect the health of other farmers. Breeding quality
[0003] For this reason, an antibacterial fish medicine and its processing method are disclosed in the Chinese invention patent specification whose application date is September 29, 2010, and the patent number is ZL201010296388.6. Sugar, 18-80% starch and 1.2-20% veterinary antibacterial drugs; the advantage is that this method uses chitosan and starch as carriers, and veterinary antibacterial drugs as drug models to make antibacterial fish medicines. The drug carrier made of polysaccharide and starch is insoluble in water, has no pollution to water quality, and can be naturally degraded in water or fish, and the degradation products have no toxic side effects on the environment. Drugs stored in this carrier are released slowly in water. It can ensure that most of the medicines are eaten by the farmed aquatic animals, and at the same time avoid the adverse effects of veterinary antimicrobials on the entire aquaculture waters; however, in actual use, it is found that the structure of the above antibacterial fishery medicines is not yet compact, and it is easier to sprinkle into seawater If it is not swallowed by the cultured animals immediately, it will easily lead to the loss of the drug in the seawater

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment one: a kind of processing method of antibacterial fish medicine, its concrete processing step is:

[0018] (1) Add 10 grams of starch into 75ml of water, and heat in a water bath at 80°C until the starch is completely gelatinized to obtain a viscous starch solution with a mass fraction of 11.8%;

[0019] (2) Slowly add 1.8g of gelatin into the above starch solution, fully dissolve the gelatin at a temperature of 80°C, and obtain a gelatin / starch solution system with a gelatin mass fraction of 2.1%;

[0020] (3) Slowly add 5.6g of chitosan into the above gelatin / starch solution system in batches, and control the temperature at 60°C, stir well to mix chitosan and gelatin / starch solution system evenly, and obtain the mass fraction of chitosan It is a 6.2% starch / chitosan / gelatin solution system, in which the mass ratio of starch, chitosan and gelatin is 4:3:1;

[0021] (4) Add 4g of antibacterial drug to the above starch / chitosan / gelatin solution system, and he...

Embodiment 2

[0025] Embodiment two: a kind of processing method of antibacterial fish medicine, its concrete processing step is:

[0026] (1) Add 16 grams of starch into 75ml of water, and heat in a water bath at 80°C until the starch is completely gelatinized to obtain a viscous starch solution with a mass fraction of 17.58%;

[0027] (2) Slowly add 4g of gelatin to the above starch solution, fully dissolve the gelatin at a temperature of 80°C, and obtain a gelatin / starch solution system with a gelatin mass fraction of 4.21%;

[0028] (3) Slowly add 12g of chitosan into the above-mentioned gelatin / starch solution system in batches, and control the temperature at 60°C, stir well to mix chitosan and gelatin / starch solution system evenly, and obtain the mass fraction of chitosan as follows: 11.21% starch / chitosan / gelatin solution system, in which the mass ratio of starch, chitosan and gelatin is 4:3:1;

[0029] (4) Add 4g of antibacterial drug to the above starch / chitosan / gelatin solution s...

Embodiment 3

[0034] Embodiment three: a kind of processing method of antibacterial fish medicine, its concrete processing step is:

[0035] (1) Add 18.7 grams of starch into 75ml of water, and heat in a water bath at 85°C until the starch is completely gelatinized to obtain a viscous starch solution with a mass fraction of 20%;

[0036] (2) Slowly add 4.7g of gelatin into the above starch solution, fully dissolve the gelatin at a temperature of 80°C, and obtain a gelatin / starch solution system with a gelatin mass fraction of 4.8%;

[0037] (3) Slowly add 14g of chitosan into the above-mentioned gelatin / starch solution system in batches, and control the temperature at 60°C, stir well to mix chitosan and gelatin / starch solution system evenly, and obtain the mass fraction of chitosan as follows: 12.5% ​​starch / chitosan / gelatin solution system, in which the mass ratio of starch, chitosan and gelatin is 4:3:1;

[0038] (4) Add 20 g of antimicrobials to the above starch / chitosan / gelatin solutio...

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Abstract

The invention discloses an antibiosis fishing medicament processing method, and has the advantage that the antibiosis fishing medicament prepared by the method contains a macro-molecule system of starch / chitosan / gelatin, and the system can form a macro-molecule interpenetrating network structure, thereby the antibiosis fishing pills prepared by the method have an obviously improved stability in seawater and are not easy to be dispersed; in addition, gelatin, chitosan and starch three compositions belong to natural large molecules which are friendly to environment, and in the preparation process, water is used as a solvent for starch dextrinization at first, and then another two compositions are gradually added; according to detection, the antibiosis fishing medicament obtained by the processing method has the advantages of uniform internal porosity structure, large porosity, uniformly distributed apertures, good connectivity between apertures, thereby the fishing medicament can be uniformly distributed in the carrier.

Description

technical field [0001] The invention relates to a processing of fishery medicine, in particular to a processing method of antibacterial fishery medicine. Background technique [0002] In coastal cities, aquaculture plays a pivotal role in economic development, and in order to prevent diseases of aquatic animals, antibacterial drugs (such as florfenicol, etc.) must be put into the breeding area. The current drug delivery method is generally to put it directly or mix it into the feed, but because the antibacterial drug is easily dissolved in the water after contacting the waters, first of all, its drug delivery efficiency is too low to ensure that fish, shrimp and other aquatic animals eat it, and it cannot Estimate the amount of food and medicine for each aquatic animal, so its efficacy cannot be guaranteed, and it is very blind; secondly, it is also easy to pollute the water quality of the water area. Since the water area is mobile and public, it will also affect the health ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/16A61K47/42A61K47/36A61K45/00A61K31/165A61K31/65A61K31/496A61P31/04
Inventor 竺亚斌陈浩娇郑燕华蔡海光王国良
Owner NINGBO UNIV
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