Heat tranferring circular reactor with external heat exchanging center and application

Abstract

An annular reactor able to remove heat by external heat exchange center for preparing the chromatographic filler is composed of top cover with feeding inlet and exhaust outlet, bottom cover, hollow cylinder between said top and bottom covers, and a circulating water tube arranged in said hollow cylinder and possing through said both covers. Its advantages are continuous feeding and uniform temp distribution.

Description

technical field [0001] The invention relates to the preparation of chromatographic fillers, in particular to an external heat exchange center heat transfer loop reactor and its application. Background technique [0002] The monolithic material has become a very attractive chromatographic packing due to its superior kinetic properties, and is known as the fourth-generation chromatographic stationary phase. Compared with the traditional granular packing, the monolithic packing is composed of a single porous body including micropores (less than 2nm), mesopores (2-50nm) and macropores (greater than 50nm). The mesopores and macropores provide channels for fluid flow. The small pores provide the appropriate internal surface area. Its pores are highly internally connected, forming a sponge-like pore network channel, and the separated molecules (transmission mechanism of substances in it) are transferred to the active sites on the surface of the pores by convection, so the migratio...

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Problems solved by technology

[0005] Scale-up techniques for both types of monolithic columns face serious difficulties

By increasing the diameter, the volume of the disc-shaped monolithic material can be enlarged. However, the mechanical strength of the filler and the uniform distribution of the sample on the monolithic filler are two major difficulties that are difficult to overcome, which limits this method [Document 6.Application of compact porous tubes for preparative isolation of clottingfactor VIII from human plasma; Strancar, A.; Barut, M.; Podgornik, A.; Koselj, P.; Schwinn, H.; .Chromatogr.A, 1997, 760, 117~123], in addition, for rod-type monolithic fillers enlarged in the radial direction, due to the difficulty of obtaining a monolithic column with uniform pore structure, the largest chromatographic column reported is 12mL with a diameter of 16mm [document 3]

The second logical way to scale up is to increase its length. The pressure drop of this type of column becomes the main problem. Even if the flow rate is only 3.5mL / min, the pressure exceeds 10Mpa [Reference 7.Modified poly(glycidylmetharylate-co-ethylene dimethacrylate) continuous rod columns for preparative-scale ion-exchange chromatography of proteins; Svec F.; Frechet, J.M.J.; J.Chromatogr.A, 1995, 702, 89~95]

Although the heat of reaction can be reduced by adjusting the initial reaction temperature, the ratio of monomer to crosslinking agent, the composition and content of porogen, the type and amount of initiator, etc., it is only suitable for the preparation of small-volume bulk fillers. The preparation of bulky monolithic materials has no successful industrial examples

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