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Chloro alkaloid compound and preparation and application thereof

A technology of alkaloids and compounds, applied in the fields of insecticides, bacteriostats, and algicides, can solve the problems of biological and human health hazards, pollution, and serious residues

Inactive Publication Date: 2013-01-16
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the 20th century, the extensive use of chemically synthesized pesticides has brought serious pollution to water bodies and soils. More than 2 / 3 of the pesticides have directly penetrated into the environment, and the residues are very serious, causing direct and potential harm to organisms and human health.

Method used

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  • Chloro alkaloid compound and preparation and application thereof
  • Chloro alkaloid compound and preparation and application thereof
  • Chloro alkaloid compound and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The chlorinated alkaloid compound derived from endophytic fungi of seaweed is represented by formula (I).

[0025]

Embodiment 2

[0027] The preparation method of the alkaloid compound shown in formula (I):

[0028] Take the fungus Aspergillus versicolor (Aspergillus versicolor) DL-29 strain that grew well on the plate, cut it into small pieces and inoculate it in PDB liquid medium, put 300mL medium in each 1L triangular flask, 50 bottles in total, and ferment statically at room temperature for 30 One-half volume of ethyl acetate was added to the fermented liquid to kill fungi, filtered, and the mycelia and fermented liquid were collected respectively. The PDB liquid medium consists of 200 milliliters of potato juice per liter, 20 grams of glucose, 5 grams of peptone, 3 grams of yeast extract, 500 milliliters of aged sea water, and 300 milliliters of distilled water. The fungus Aspergillus versicolor (Aspergillus versicolor) DL-29 strain was preserved in China Center for Type Culture Collection CCTCC on November 25, 2011, the preservation number is CCTCC M 2011421, the classification name is Aspergillus ...

Embodiment 3

[0036] The difference from Example 2 is that

[0037]Take the fungus Aspergillus versicolor (Aspergillus versicolor) DL-29 strain that grew well on the plate and inoculate it in JY liquid medium, put 300mL medium in each 1L Erlenmeyer flask, 50 bottles in total, ferment statically at room temperature for 20 days, add fermentation broth One-half volume of ethyl acetate kills fungi, filters, and collects mycelium and fermentation broth respectively. The JY liquid medium consists of 500 milliliters of Jerusalem artichoke tuber juice per liter, 10 grams of glucose, 2.0 grams of sodium nitrate, and 500 milliliters of aged seawater.

[0038] Collect about 15L of fermentation broth, extract three times with ethyl acetate, and concentrate under reduced pressure; crush the mycelium, extract with ethanol three times, then extract with ethyl acetate, and concentrate under reduced pressure; the concentrate is detected by thin layer chromatography (petroleum ether- Ethyl acetate 20-0:1, s...

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Abstract

The invention relates to the fields of algistats, pesticides and bacteriostatic agents, in particular to a chloro alkaloid compound which is a source of seaweed endophytic fungi and the preparation and application of the chloro alkaloid compound. The specific structural formula is shown in I, and the preparation method comprises the following steps: inoculating Aspergillus versicolor DL-29 into a fungi liquid medium for fermental cultivation, and purifying the fermentation product to obtain the chloro alkaloid compound shown in the formula I. An algistatic activity experiment shows that the median inhibitory concentration of the chloro alkaloid compound is 6.3 microgram / ml, and the compound has insecticidal and bacteriostatic activities.

Description

technical field [0001] The invention relates to the fields of algicides, insecticides and bacteriostats, in particular to a chlorinated alkaloid compound derived from seaweed endophytic fungi and its preparation and application. Background technique [0002] With the rapid development of the national economy, the problem of marine pollution has become increasingly serious, especially the increase in the degree of eutrophication, resulting in frequent occurrence of harmful red tides, which have brought serious harm to the marine environment, marine life and coastal aquaculture. Therefore, the development of harmful Red tide microalgae inhibitors have important application value. [0003] Since the 20th century, the extensive use of chemically synthesized pesticides has brought serious pollution to water bodies and soils. More than 2 / 3 of the pesticides have directly penetrated into the environment, and the residues are very serious, causing direct and potential harm to organi...

Claims

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Application Information

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IPC IPC(8): C07D471/22A01N43/90A01P13/00A01P1/00A01P7/00C12P17/18C12R1/66
Inventor 季乃云苗凤萍
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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