Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Stemona sessilifolia alkaloid salt and its pharmaceutical application

A technology of tributine and medicines, applied in the field of organic acid salts of tributine and its pharmaceutical application, can solve problems such as adverse reactions, multiple and serious, and achieve the effect of practical therapeutic activity

Inactive Publication Date: 2013-01-16
SHANGHAI YIZHI MEDICAL TECH
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of antitussive drugs, but these existing drugs are likely to cause multiple and severe adverse reactions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stemona sessilifolia alkaloid salt and its pharmaceutical application
  • Stemona sessilifolia alkaloid salt and its pharmaceutical application
  • Stemona sessilifolia alkaloid salt and its pharmaceutical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Christine chenodeoxycholate.

[0048] Dissolve 300 grams of centristine and 200 grams of chenodeoxycholic acid in 4 liters of boiling ethanol. The hot solution was filtered through diatomaceous earth, then slowly cooled under gentle stirring, and stood for several hours in a temperature environment of 0-5°C, the crystals of thyristine chenodeoxycholate were precipitated, and the thyristine was filtered out Chenodeoxycholate crystals were washed with ethanol and dried under vacuum at 50°C to yield 441 g of product.

Embodiment 2

[0050] Christine chenodeoxycholate.

[0051] Stir 391.04 g (0.5M) of centristine chenodeoxycholic acid salt and 196.29 g (0.5M) of chenodeoxycholic acid in 5 liters of refluxing ethanol until all the solids are dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Stand for several hours in a temperature environment of 0-5°C, the crystals of thyristine chenodeoxycholate are precipitated, the crystals of thyristine chenodeoxycholate are filtered out, washed with ethanol and placed under vacuum conditions at 50°C Drying under the hood yielded 432 g of product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a stemoninine glycyrrhetate or its pharmaceutically acceptable solvate, and its application in the preparation of cough treatment and / or alleviation medicines.

Description

field of invention [0001] The present invention relates to the field of medicinal chemistry, in particular, the present invention relates to a kind of organic acid salt of centristine and its pharmaceutical application. Background technique [0002] Cough is a common disease, and there are many reasons for coughing. At present, there are many kinds of antitussive drugs, but these existing drugs are likely to cause multiple and severe adverse reactions. Certain compounds with antitussive activity (stemoninine) are described in US Patent No. US Patent 7,867,998B2 and Chinese Patent Application No. 200710045498.3. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Some of these compounds...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J9/00C07D491/22A61K31/575A61K31/55A61P11/14
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com