Production method for producing medicine for treating hepatitis B by periplaneta americana extract

A technology for Periplaneta americana and hepatitis B, which is applied in the directions of pharmaceutical formulation, drug combination, drug delivery, etc., can solve the problem that Periplaneta americana is rarely reported in the treatment of hepatitis B, so as to improve the dissolution rate of drugs and avoid containing protein , the effect of improving the cure rate

Active Publication Date: 2013-01-23
KUNMING SINOWAY NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, Periplaneta americana is...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The production method for preparing the medicine for treating hepatitis B from the extract comprises the following steps:

[0035] A, mixing: get 500 parts of Periplaneta americana extract fine powder that treats hepatitis B usefulness, add 200 parts of starch, 300 parts of microcrystalline cellulose, add 2 parts of magnesium stearate and mix homogeneously, obtain medicated powder;

[0036] B, pharmacy: the product obtained in step A is filled in the hard capsule according to the specification of 0.3g per grain, and the capsule for treating hepatitis B must be prepared with the Periplaneta americana extract.

[0037] The extracting method of the American cockroach extract used for the treatment of hepatitis B comprises the following steps:

[0038] A, inactivation and pulverization: the fresh worms of Periplaneta americana are killed by hot water at 80°C, dried in the range of 60°C ± 5°C under temperature control, pulverized, and passed through a 24-mesh sieve to obtai...

Embodiment 2

[0047] A production method for preparing a medicine for treating hepatitis B from an extract of Periplaneta americana, comprising the following steps:

[0048] A, mixing: get 500 parts of Periplaneta americana extract fine powder that treats hepatitis B usefulness, add 250 parts of starch, 180 parts of microcrystalline cellulose 7 parts of silicon dioxide, add 1 part of magnesium stearate and mix homogeneously, obtain medicated powder ;

[0049] B, pharmacy: the product obtained in step A is filled in the hard capsule according to the specification of 0.3g per grain, and the capsule for treating hepatitis B must be prepared with the Periplaneta americana extract.

[0050] After testing, each capsule contains 61 mg of Periplaneta americana extract in terms of combined amino acids.

[0051] The extracting method of the American cockroach extract used for the treatment of hepatitis B comprises the following steps:

[0052] A, inactivation and pulverization: the fresh worm of Pe...

Embodiment 3

[0061] A production method for preparing a medicine for treating hepatitis B from an extract of Periplaneta americana, comprising the following steps:

[0062] A. Mixing: Get 500 parts of Periplaneta americana extract fine powder for the treatment of hepatitis B, add 430 parts of microcrystalline cellulose, 70 parts of silicon dioxide, add 10 parts of 50% alcohol to make soft material, 16 mesh screen Granulate, dry under normal pressure at 50-60°C for 3-5 hours, until the water content of the granules is 5-8%, take out the granules and let cool to room temperature, add 1 part of magnesium stearate, and granulate to obtain granules.

[0063] B, pharmacy: the product obtained in step A is pressed into tablets and film-coated by every 0.6g specification, and the film-coated tablets for treating hepatitis B must be prepared with the Periplaneta americana extract;

[0064] The extracting method of the American cockroach extract used for the treatment of hepatitis B comprises the fo...

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PUM

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Abstract

The invention provides a production method for producing a medicine for treating hepatitis B by a periplaneta americana extract, comprising the following steps of: A, mixing, and B, preparing the medicine. A method for extracting the periplaneta americana extract for treating hepatitis B comprises the following steps of: a, inactivating and crushing, b, extracting, c, primarily concentrating, d, degreasing and adsorbing, e, eluting, f, secondarily concentrating and g, drying and crushing. The medicine prepared by adopting the method can effectively control the hydrolysis of active ingredients for generating an inhibition effect on hepatitis B and increase the cure rate of hepatitis B, has an extraction rate of 3-5% for the active ingredients for hepatitis B, and has a total effective rate of 80-95% for the HBeAg (hepatitis Be antigen) negative conversion ratio and the HBV-DNA (hepatitis B virus-deoxyribose nucleic acid) negative conversion ratio of patients with chronic hepatitis B and carriers with hepatitis B virus. Via the method, the physical properties of the medicine are improved and the curative effect of the medicine is enhanced; the own smell of the medicine is effectively controlled, and the patients can conveniently take the medicine; simultaneously, harmful allergens in the medicine can be effectively reduced; and the method is low in cost and high in safety.

Description

technical field [0001] The invention relates to a production process of medicines, in particular to a production method for producing medicines for treating hepatitis B with extracts of Periplaneta americana. Background technique [0002] The American cockroach (Periplaneta americana) is the largest insect in the cockroach family. The adult body is 29-35 mm long, reddish brown, and the wings are longer than the end of the abdomen. The antennae are very long, and there is a large butterfly-shaped brown stripe in the middle of the pronotum, and the rear edge of the stripe has a complete yellow stripe. It is native to South America , a wide range of eating habits, like sugar and starch, polluted food. [0003] Periplaneta americana is a traditional Chinese medicinal material, and adults are used as medicine. It is cold in nature, salty in taste, poisonous, pungent, and has the functions of dispelling blood stasis, eliminating stagnation, detoxifying, diuresis, and reducing sw...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/48A61K9/30A61P1/16A61P31/20
Inventor 何道峰郝振平
Owner KUNMING SINOWAY NATURAL PHARMA
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