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Instant thickener comprising probiotics for hot or cold foods and beverages to be administered to dysphagic patients

一种吞咽困难、增稠剂的技术，应用在抗真菌剂、动物饲料、使用微生物的方法等方向，达到保留健康益处的效果

Inactive Publication Date: 2013-02-20
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The need to rely on thickened food compositions limits the use of existing food compositions for dysphagia patients

Method used

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  • Instant thickener comprising probiotics for hot or cold foods and beverages to be administered to dysphagic patients
  • Instant thickener comprising probiotics for hot or cold foods and beverages to be administered to dysphagic patients
  • Instant thickener comprising probiotics for hot or cold foods and beverages to be administered to dysphagic patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Methodology

[0110] Bacterial agents:

[0111] The health benefits of live probiotics on the host immune system are generally considered to be strain-specific. Probiotics that induce high levels of IL-10 in vitro and / or induce low levels of pro-inflammatory cytokines (PBMC assay) have been shown to be potent anti-inflammatory strains in vivo (Foligné, B. et al., 2007, World J. Gastroenterol. 13 : 236-243).

[0112] The anti-inflammatory properties of heat-treated probiotics were investigated using several probiotic strains. These strains are Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, ​​Bifidobacterium lactis NCC 2818, Lactobacillus paracasei NCC 2461, Lactobacillus rhamnosus NCC 4007, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825) and Escherichia coli Nissle. Several starter culture strains were also tested, including some commercially used for the p...

Embodiment 2

[0135] Methodology

[0136] Bacterial agents:

[0137] Five probiotic strains were used to study the immune-enhancing properties of non-replicating probiotics: 3 Bifidobacterium species (Bifidobacterium longum NCC3001, Bifidobacterium lactis NCC2818, Bifidobacterium breve NCC2950) and 2 species of Lactobacillus (Lactobacillus paracasei NCC2461, Lactobacillus rhamnosus NCC4007).

[0138] Bacterial cells were grown on MRS and fermented batchwise at 37°C for 16-18 hours without pH control. Bacterial cells were spun down (5,000 xg, 4°C) and resuspended in phosphate buffered saline before dilution in saline to achieve a final concentration of approximately 10E10 cfu / mL. Heat-treat Bifidobacterium longum NCC3001, Bifidobacterium lactis NCC2818, Lactobacillus paracasei NCC2461, and Lactobacillus rhamnosus NCC4007 in a water bath at 85° C. for 20 minutes. Bifidobacterium breve NCC2950 was heat-treated in a 90°C water bath for 30 minutes. The heat-treated bacterial suspension was a...

Embodiment 3-5

[0153] Food Thickeners:

[0154] Food Modified Starch (Corn).

[0155] Probiotics: 10 9 cfu / g Lactobacillus johnsonii La1

[0156] Thickened water:

[0157] Ingredients: Water, Food Modified Starch (Corn), Sugar, Natural Flavouring, Phosphoric Acid

[0158] Osmolality (mOsm / kg water) 139

[0159] Free water 92-94%

[0160] 70-80kcal / customer

[0161] 25mg sodium / guest

[0162] 17-19mg carbohydrates / guest

[0163] 221-226ml water / customer

[0164] Probiotics: 10 9 cfu heat-treated (75°C, 20 minutes) Bifidobacterium longum NCC 3001 / guest

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Abstract

The present invention relates to the fields of hydration and nutrition for dysphagic patients. In particular, the present invention relates to thickeners comprising probiotic microorganisms and to compositions comprising such thickeners. The probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic microorganisms.

Description

field of invention [0001] The present invention relates to the field of hydration and nutrition of patients with dysphagia. In particular, the present invention relates to thickeners comprising probiotic microorganisms and compositions comprising such thickeners. The probiotic microorganism may be a non-replicating probiotic microorganism, such as a biologically active, heat-treated probiotic microorganism. Background technique [0002] Dysphagia is the medical term for the symptoms of difficulty swallowing. Dysphagia can lead to a variety of problems that affect a patient's ability to safely swallow liquids or food. [0003] It is estimated that more than 15,000,000 Americans suffer from dysphagia. Dysphagia can be caused by a variety of conditions that can occur throughout a person's life. For example, traumatic brain injury, cerebral palsy, and Parkinson's disease can cause swallowing difficulties. [0004] When appropriate steps are not taken to manage dysphagia, pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A23L1/05A61P1/00A61P29/00A23L7/10A23L7/104A23L29/20A23L33/00A61K35/744A61K35/745A61K35/747
CPCA23K1/009A61K35/747A23L1/3014A23Y2220/43A23L1/296C12N1/36A23K10/18A23L33/40A23L33/135A61K35/74A61K35/744C12N1/005C12N1/20A61K35/745A61P1/00A61P1/02A61P1/04A61P1/12A61P1/14A61P11/00A61P11/02A61P11/04A61P11/06A61P13/02A61P15/00A61P15/02A61P17/00A61P17/02A61P21/02A61P27/02A61P27/16A61P29/00A61P3/00A61P3/02A61P31/00A61P31/04A61P31/06A61P31/10A61P31/12A61P31/18A61P31/22A61P33/00A61P35/00A61P37/00A61P37/02A61P37/04A61P37/06A61P37/08A61P43/00A61P7/00A61P9/04Y02A50/30A23V2400/151A23V2400/113A23V2400/123A23V2400/125A23V2400/165A23V2400/173A23V2400/175A23V2400/231A23V2400/249A23V2400/519A23V2400/531A23V2400/533A23V2002/00
Inventor A·梅赛尼尔S·努特恩G·普里乌特
Owner NESTEC SA
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