Purpose of bitter marrow squash extracts in anti-gout medicine preparation

A technology for zucchini and anti-gout is applied in the field of use of bitter zucchini extract in the preparation of anti-gout medicines, which can solve the problem that no bitter zucchini water extract or bitter zucchini alcohol extract is found, and can relieve joint swelling, Improves mobility and lowers uric acid levels

Active Publication Date: 2013-03-06
黑龙江拜欧迪生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the invention patent does not find that bitter zucchini water extract or bitter zucchini alcohol extract can be used to prepare anti-gout drugs

Method used

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  • Purpose of bitter marrow squash extracts in anti-gout medicine preparation
  • Purpose of bitter marrow squash extracts in anti-gout medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Bitter Zucchini Water Extract and Bitter Zucchini Ethanol Extract.

[0030] Specifically, the bitter zucchini water extract or the bitter zucchini alcohol extract is prepared through the following preparation steps:

[0031] (1) Take 100 kilograms of semi-ripe bitter zucchini fruits, peel them, then cut the pulp into small pieces, add 25 kilograms of water, cook for 4 hours, and make a paste;

[0032] (2) Remove the paste and dry it in the sun to obtain 3.4 kg of dried raw medicine;

[0033] (3) Dry pulverize the original drug into the original drug powder and store it at room temperature;

[0034](4) Take 100 grams of the original drug powder, dissolve it in 1000 ml of distilled water, shake and extract for 8 hours, then centrifuge and filter to obtain the supernatant, then concentrate and dry to obtain 11 grams of bitter zucchini water extract; 100 grams of the original drug powder, add 1000 milliliters of 95% ethanol, shake and extract for 8 hours, t...

Embodiment 2

[0036] Acute Toxicity Analysis of Bitter Zucchini Water Extract and Bitter Zucchini Alcohol Extract in Mice.

[0037] The bitter zucchini water extract and the bitter zucchini alcohol extract prepared in Example 1 were dissolved in 0.5% sodium carboxymethylcellulose solution to prepare different concentrations (the bitter zucchini water extract concentration was 500 mg / mL and 100 mg / mL; Bitter zucchini alcohol extract concentration of 500mg / mL and 100mg / mL) oral liquid, oral administration experiments were carried out on mice.

[0038] Two groups of 8-week-old BALB / c mice (Charles River Company, USA), 10 in each group (5 males and 5 females), were given a single dose of 5 g / kg and multiple doses of 1 g / kg (QD X15) The water extract of bitter zucchini and the alcoholic extract of bitter zucchini were administered, and then observed for 1 week and 4 weeks, respectively. Weigh every two days.

[0039] After the experiment, the tested mice were sacrificed for pathological analys...

Embodiment 3

[0043] Effects of water extract and alcohol extract of bitter zucchini on reducing serum uric acid levels in oxonate potassium-induced hyperuricemic mice.

[0044] The water extract of bitter zucchini prepared in Example 1 and the alcoholic extract of bitter zucchini were dissolved in 0.5% sodium carboxymethylcellulose solution respectively to prepare oral liquids with a concentration of 5 mg / mL and 2.5 mg / mL, and the mice were treated with Oral administration experiment.

[0045] Take 5 groups of 8-week-old BALB / c mice, 10 female BALB / c mice in each group, and 4 groups of test mice were given 25mg / kg and 50mg / kg of bitter zucchini water extract or bitter zucchini alcohol extract respectively Oral solution, and the control group was given placebo (0.5% carboxymethylcellulose sodium solution) in the same way.

[0046] Mice were housed individually and allowed free access to food. One hour before the last drug feeding, BALB / c mice were intraperitoneally injected with 280 mg / 1 ...

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Abstract

The invention relates to a new purpose of bitter marrow squash extracts or bitter marrow squash ethanol extracts in the medical science, in particular to a new purpose of bitter marrow squash extracts or bitter marrow squash ethanol extracts in the anti-gout medicine preparation. Studies find that the bitter marrow squash extracts or the bitter marrow squash ethanol extracts can effectively reduce the uric acid level, relieve the arthrocele degree, improve the action capability and have the anti-gout efficiency, no side effect exists, the efficiency is high, and in addition, the gout cannot be rebounded after medicine discontinuance. Therefore, the bitter marrow squash extracts or the bitter marrow squash ethanol extracts can be used for preparing medicine for treating gout, and the huge application potential of the bitter marrow squash is further developed.

Description

technical field [0001] The invention relates to a new application of bitter zucchini extract in medicine, in particular to a new application of bitter zucchini water extract or bitter zucchini alcohol extract in preparing anti-gout medicine. Background technique [0002] There is a substance called purine in the human body, and when its metabolism is disturbed, it will cause gout. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid increases or the excr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61P19/06
Inventor 钟荣张南简志光傅建平
Owner 黑龙江拜欧迪生物医药科技有限公司
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