Pharmaceutical composition suitable for mild disease of senile vascular dementia

A technology of vascular dementia and composition, applied in the direction of drug combination, medical raw materials derived from ferns/filamentous plants, active ingredients of heterocyclic compounds, etc.

Inactive Publication Date: 2013-04-10
SICHUAN GUANGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Jiuwei Yinao Granules in traditional Chinese medicine prescriptions are made from ginseng, Danshen, Polygonum multiflorum, Psoraleae, Poria cocos, Radix Paeoniae Rubra, Chuanxiong, Shichangpu, and Polygala nine herbs. It has a certain improvement effect, and also has an antithrombotic effect. It is used for mild vascular dementia in the elderly, and the curative effect is exact, but the dosage is three times a day, 5g each time. room for further improvement

Method used

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  • Pharmaceutical composition suitable for mild disease of senile vascular dementia
  • Pharmaceutical composition suitable for mild disease of senile vascular dementia
  • Pharmaceutical composition suitable for mild disease of senile vascular dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Experiment A: Extraction of Poria cocos polysaccharide

[0057] Rough extraction method Pulverize Poria with a pulverizer until it can pass through a 60-mesh sieve. Take a total of 15g of Poria cocos powder and dissolve it in 3000ml of 0.5mol / L NaOH solution at 3°C. Add the tetrafluoroethylene rotor and stir in a magnetic stirrer until the powder is completely dissolved, and the solution is viscous at this time. Store in refrigerator at 4°C overnight. Suction filtration the next day, discard the residue and retain the liquid. The filtrate is neutralized with 10% acetic acid solution until its pH is measured between 6-7 with a wide pH test paper. An equal amount of 95% ethanol was added and left overnight at 3°C. Suction filtration the next day to obtain the precipitate. Then, after dialysis with running water for 2 days, it was washed successively with 900ml of distilled water, 300ml of absolute ethanol, 300ml of acetone, and 200ml of diethyl ether. Afterwards, pu...

Embodiment 2

[0064] Embodiment 2: the preparation of granule

[0065] Weigh 0.2g of ginsenoside Rg1, 0.3g of tanshinone IIA, 0.075g of emodin, and 3.3g of polysaccharide. Beta-cyclodextrin and sodium cyclamate 40g, dextrin 263g, starch 600g, mix well, adopt one-step granulation method, make granules, dry, make 1000g, and obtain.

Embodiment 3

[0066] Embodiment 3: the preparation of granule

[0067] Weigh 0.2g of ginsenoside Rg1, 0.3g of tanshinone IIA, 0.075g of emodin, 3.3g of polysaccharide, 0.5g of ferulic acid, and 0.4g of β-asarone. Beta-cyclodextrin and sodium cyclamate 40g, dextrin 263g, starch 600g, mix well, adopt one-step granulation method, make granules, dry, make 1000g, and obtain.

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Abstract

The invention relates to a pharmaceutical composition suitable for mild disease of senile vascular dementia. The pharmaceutical composition is characterized by comprising 0.3-1.3g of tanshinone II A, 0.2-1.1g of ginsenoside Rg1, 0.075-0.3g of rheum emodin and 3.3-14g of pachymaran; preferably, the pharmaceutical composition also comprises components such as red flower, angelica sinensis, cinnamon, curcuma zedoary, euonymus alatus, caulis spatholobi, selaginella tamariscina, herba lycopi, rhodiola rosea, the fruit of Chinese wolfberry and the like for activating blood and tonifying qi.

Description

technical field [0001] The invention relates to a pharmaceutical composition suitable for mild senile vascular dementia. Background technique [0002] Many countries and regions in the world today have entered an aging society. According to foreign statistics, among the elderly over 65 years old, 2-5% are obviously demented, and those over 80 years old account for 15-20%. If combined with light and moderate, it is estimated that the above-mentioned figures will exceed 2-3% times as much. Senile dementia mainly includes two types: Senile Dementia of the Alzheimer type (SDAT) and vascular dementia (Vascular Dementia, VD). Both can exist alone or in combination. Alzheimer type is more common in western countries. According to western statistics, it accounts for about 65% of senile dementia and currently accounts for the fourth cause of death. Vascular dementia is mainly caused by pathological processes such as multiple cerebral infarction, lacunar infarction, single infarct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/704A61K31/58A61K31/122A61K31/192A61K31/09A61K31/7048A61K31/37A61K36/11A61K36/232A61K36/286A61K36/37A61K36/41A61K36/486A61K36/53A61K36/54A61K36/69A61K36/71A61K36/815A61K36/9066A61P25/28
Inventor 曾德成李珏袁永长徐秋萍向双
Owner SICHUAN GUANGDA PHARMA
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